# 5-Amino-1MQ

> NNMT-blocking small molecule for research on fat-cell and NAD+ metabolism

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/5-amino-1mq/
- Brand: Peptide Medix EU
- Category: [Fat-Loss & Metabolic Peptides](https://peptidemedixeu.com/en/collections/fat-loss-peptides/)
- Purity: ≥99% by HPLC; lot-matched COA available
- CAS number: 42464-96-0
- from €80 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 50 mg | €80 | 5-AMINO-1MQ-50-MG |
| 100 mg | €140 | 5-AMINO-1MQ-100-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 42464-96-0
- **Molecular formula:** C10H11N2+ cation, supplied as the iodide salt C10H11IN2
- **Molecular weight:** 159.21 g/mol (cation); 286.11 g/mol (iodide salt)
- **Form:** Lyophilized powder, sealed glass vial with flip-off seal
- **Purity:** ≥99% by HPLC; lot-matched COA available
- **Available sizes:** 50 mg, 100 mg
- **Solubility:** Water and bacteriostatic water; DMSO used for concentrated stocks in cell assays
- **Compound class:** Small-molecule quinolinium NNMT inhibitor
- **Molecular target:** Nicotinamide N-methyltransferase (NNMT)
- **Research areas:** Adipocyte metabolism, NAD-plus salvage, sirtuin signaling, methyl-donor flux
- **Storage (solid):** −20 °C, sealed and protected from light and moisture
- **Storage (in solution):** 2–8 °C, protected from light; use within the study window

## Description

Despite its place in a peptide catalogue, 5-Amino-1MQ is a small molecule: it blocks nicotinamide N-methyltransferase (NNMT). That enzyme moves a methyl group from S-adenosylmethionine onto nicotinamide, yielding 1-methylnicotinamide — a step that spends a methyl donor and, at the same time, removes nicotinamide that could have been recycled into NAD-plus. NNMT is strongly upregulated in the fat tissue of obese animal models, so inhibiting it is the natural experiment for asking whether this methylation flux actively drives sluggish metabolism or simply accompanies it.

Chemically it is a quinolinium compound delivered as the iodide salt, and its permanent positive charge is what governs handling and study design. Most published studies use cultured adipocytes, reading out intracellular NAD-plus, sirtuin activity, lipolysis and mitochondrial respiration once NNMT is inhibited; others use diet-induced obese rodents and track fat-pad weight alongside metabolic markers. Labs also reach for it as a tool compound whenever the contribution of NNMT in a particular tissue has not yet been pinned down.

## Frequently asked questions

### Is 5-Amino-1MQ actually a peptide?

No. It is a quinolinium small molecule whose job is to inhibit NNMT. We list it among the metabolic research compounds because of the questions it is used to answer, yet structurally it shares nothing with the peptide sequences elsewhere in the range.

### Why does the specification show two molecular weights?

The quinolinium cation — the active part — weighs 159.21 g/mol, whereas the powder you receive is the iodide salt at 286.11 g/mol. Any molar calculation has to include the counter-ion, so both values are printed on the spec sheet.

### Which purity data and paperwork come with it?

Each lot is assayed by HPLC to a minimum of 99%, and its certificate of analysis can be requested at any time. That COA carries the same lot number as the vial you receive, keeping the analytical record traceable to the exact material on your bench.

### How do researchers show that NNMT is really inhibited?

The usual approach is to quantify 1-methylnicotinamide, the enzyme's own product, or to run an NNMT knockdown arm for comparison. Changes further downstream, such as NAD-plus or lipolysis, cannot by themselves prove the enzyme was hit.

### What are the storage conditions?

Store the unopened solid at −20 °C, shielded from light and humidity. Once dissolved, keep it at 2–8 °C in the dark and use it inside the window your protocol documents. Split stocks into aliquots to avoid warming the same tube again and again.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/5-amino-1mq/