# Argireline (Acetyl Hexapeptide-8)

> Acetyl hexapeptide-8 (EEMQRR), the benchmark cosmetic signal peptide — 10 mg and 50 mg

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/argireline/
- Brand: Peptide Medix EU
- Category: [Cosmetic Signal Peptides](https://peptidemedixeu.com/en/collections/cosmetic-peptides/)
- Purity: ≥99% by HPLC with mass-spectrometric identity check; COA per lot
- CAS number: 616204-22-9
- from €46 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 10 mg | €46 | ARGIRELINE-10-MG |
| 50 mg | €131 | ARGIRELINE-50-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 616204-22-9
- **Molecular formula:** C34H60N14O12S
- **Molecular weight:** 888.99 g/mol
- **Amino acid sequence:** Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2
- **Peptide class:** Cosmetic signal peptide; SNAP-25 N-terminal fragment analog
- **Form:** White lyophilized powder in a sealed glass vial
- **Purity:** ≥99% by HPLC with mass-spectrometric identity check; COA per lot
- **Available sizes:** 10 mg, 50 mg
- **Solubility:** Freely soluble in water and bacteriostatic water
- **Storage (lyophilized):** −20 °C, sealed, away from light and moisture
- **INCI name:** Acetyl Hexapeptide-8 (formerly acetyl hexapeptide-3)
- **Research areas:** SNARE assembly, exocytosis interference, expression-line formulation studies
- **Storage (in solution):** 2–8 °C, short-term; methionine is oxidation-sensitive

## Description

Argireline is the brand name of acetyl hexapeptide-8, a six-amino-acid peptide (Glu-Glu-Met-Gln-Arg-Arg) with an acetylated N-terminus and an amidated C-terminus. First registered as acetyl hexapeptide-3, it has become one of the best-researched cosmetic signal peptides, largely because it is short, dissolves easily in water and is inexpensive to characterise. Its sequence is copied from the N-terminal part of SNAP-25, a member of the SNARE complex that drives vesicle docking and fusion at nerve terminals.

In the lab it is used to study how SNARE complex formation can be disrupted from the extracellular side, and as a reference ingredient in topical formulation work where expression lines are quantified by profilometry or image analysis. Newer analogues such as SNAP-8 are measured against it, so researchers typically test both in one vehicle at equal molar concentrations.

Peptide Medix EU supplies Argireline as lyophilised powder in 10 mg and 50 mg vials, tested by an independent laboratory to ≥99% HPLC purity with a certificate of analysis for every lot, and shipped from our EU warehouse.

## Frequently asked questions

### What exactly is Argireline?

It is the trade name of acetyl hexapeptide-8, a hexapeptide with the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2 taken from the N-terminal region of SNAP-25. It ranks among the most thoroughly studied cosmetic signal peptides and serves widely as a reference material in formulation and SNARE-assembly studies.

### Are acetyl hexapeptide-8 and acetyl hexapeptide-3 the same thing?

Yes. The ingredient was first registered as acetyl hexapeptide-3 and later given the INCI name acetyl hexapeptide-8. Older publications and datasheets use the original name for the very same sequence — useful to remember when matching literature data to a current certificate of analysis.

### Is the lot independently tested, and can I view the COA?

Yes. An independent laboratory checks identity and purity of every production lot by HPLC with mass-spectrometric confirmation, and you can request the lot's certificate of analysis before buying. It lists lot number, assay result and test date, ready to file with your lab records.

### How does it differ from SNAP-8?

SNAP-8 shares the same core but adds two amino acids at the C-terminus, making it an octapeptide. Comparative studies assess binding to the SNARE interface, stability in water and performance in identical vehicles. One cannot stand in for the other in a study; they are normally tested side by side.

### What vial sizes and contents are available?

We offer 10 mg and 50 mg lyophilised vials containing pure peptide — no diluent, carrier or preservative. The 10 mg vial fits receptor and assay experiments; the 50 mg vial is intended for repeated formulation trials needing larger stock volumes.

### How should I store and dissolve it?

Keep the sealed lyophilisate at −20 °C away from light and humidity. It dissolves readily in water or bacteriostatic water. Since its methionine oxidises easily, make up solutions shortly before use, hold them at 2–8 °C and avoid cycles of freezing and thawing.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/argireline/