# Cardiogen

> AEDR (Ala-Glu-Asp-Arg) tetrapeptide for research in cardiac tissue models

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/cardiogen/
- Brand: Peptide Medix EU
- Category: [Khavinson Bioregulators](https://peptidemedixeu.com/en/collections/khavinson-bioregulators/)
- Purity: ≥99% by HPLC; lot-matched COA available
- from €63 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 20 mg | €63 | CARDIOGEN-20-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **Molecular formula:** C18H31N7O9
- **Molecular weight:** 489.48 g/mol
- **Amino acid sequence:** Ala-Glu-Asp-Arg (AEDR), linear tetrapeptide
- **Peptide class:** Khavinson short-peptide bioregulator (tetrapeptide)
- **Form:** Lyophilized powder in a sealed glass vial
- **Purity:** ≥99% by HPLC; lot-matched COA available
- **Available sizes:** 20 mg
- **Solubility:** Bacteriostatic or sterile water; readily soluble in aqueous buffers
- **Storage (lyophilized):** −20 °C, sealed and protected from light and moisture
- **Storage (reconstituted):** 2–8 °C, protected from light; use within the study window
- **Tissue association:** Heart and myocardial peptide preparations
- **Research areas:** Cardiomyocyte culture, stem-cell differentiation models, myocardial tissue, gene expression
- **Sequence relationship:** Shares the Ala-Glu-Asp core with Cortagen (AEDP) and Bronchogen (AEDL)

## Description

Cardiogen is the synthetic tetrapeptide L-alanyl-L-glutamyl-L-aspartyl-L-arginine (Ala-Glu-Asp-Arg, AEDR). It represents the heart in the Khavinson series of short-peptide bioregulators and was developed the way its siblings were: peptide extracts from cardiac tissue came first, a short candidate sequence was then isolated, and finally the synthetic tetrapeptide took over from the extract as a defined, reproducible research material.

With arginine in position four, Cardiogen has a strongly basic side chain not found in the other Ala-Glu-Asp peptides. Its guanidinium group is positively charged at neutral pH, making AEDR zwitterionic in a different sense from Cortagen or Bronchogen and changing how it interacts with negatively charged surfaces, nucleic acids and ion-exchange resins. Anyone running chromatography or binding assays across the series will notice this, as retention times and apparent affinities can differ markedly from the neutral or hydrophobic members.

Studies using AEDR include cardiomyocyte and stem-cell differentiation cultures, isolated heart-tissue preparations, expression analyses of a small gene panel and rodent work on age-related changes in myocardium. We supply Cardiogen in a 20 mg lyophilised vial, synthesised by SPPS and HPLC-purified to a ≥99% specification, with a certificate of analysis for the lot. Laboratory research use only.

## Frequently asked questions

### What is Cardiogen?

A synthetic tetrapeptide, Ala-Glu-Asp-Arg (AEDR), belonging to the Khavinson bioregulator series and linked in that body of work to cardiac tissue. It comes as a lyophilised research chemical intended solely for laboratory investigation.

### How do you confirm its purity?

Batches are tested by HPLC against a ≥99% purity specification; the certificate for your lot is available on request and lists batch number, measured purity, identity check and the physical appearance of the powder.

### Why is there no CAS number?

AEDR does not have a broadly recognised CAS registry entry, and we would rather leave the field empty than fill it with an unconfirmed number. The peptide is identified by its sequence, formula and molecular weight, each verified on the lot certificate.

### Why does the arginine matter?

At neutral pH arginine's guanidinium group is positively charged — a feature none of the other Ala-Glu-Asp peptides in the series share. It alters behaviour on chromatography columns and in binding experiments, so analytical methods usually need tweaking for Cardiogen.

### What storage does the vial need?

Unopened, keep the lyophilised vial at −20 °C in the dark and away from moisture. Once reconstituted, refrigerate at 2–8 °C for the duration of the planned work, or freeze it in single-use portions if you need it over a longer period.

---

All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/cardiogen/