# CJC-1295 with DAC

> GHRH analogue with a drug affinity complex (DAC) that binds albumin

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/cjc-1295-dac/
- Brand: Peptide Medix EU
- Category: [GHRH Analogs](https://peptidemedixeu.com/en/collections/ghrh-peptides/)
- Purity: ≥99% by HPLC; lot-matched COA available
- CAS number: 863288-34-0
- from €46 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 2 mg | €46 | CJC-1295-DAC-2-MG |
| 5 mg | €85 | CJC-1295-DAC-5-MG |
| 10 mg | €153 | CJC-1295-DAC-10-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 863288-34-0
- **Molecular formula:** C165H269N47O46
- **Molecular weight:** 3647.28 g/mol
- **Peptide class:** Long-acting GHRH analogue (GHRH-R agonist)
- **Form:** Lyophilized powder, sealed glass vial
- **Purity:** ≥99% by HPLC; lot-matched COA available
- **Available sizes:** 2 mg, 5 mg, 10 mg
- **Storage (lyophilized):** −20 °C, sealed and protected from light and moisture
- **Storage (reconstituted):** 2–8 °C, used within the study window
- **Also known as:** CJC-1295 DAC, DAC:GRF, drug affinity complex GHRH analogue
- **Structure:** Modified GRF 1-29 (D-Ala2, Gln8, Ala15, Leu27) extended with Lys30-maleimidopropionamide
- **Conjugation chemistry:** Maleimide–thiol addition to cysteine-34 of serum albumin
- **Research areas:** Sustained secretagogue signalling, receptor desensitisation, IGF-1 dynamics

## Description

CJC-1295 with DAC is a synthetic analogue of growth hormone-releasing hormone. It uses the Modified GRF 1-29 sequence as its backbone and adds a lysine at position 30 bearing a maleimidopropionyl group — the drug affinity complex (DAC). This maleimide couples to the free thiol of cysteine-34 on circulating serum albumin, creating a covalent conjugate that protects the peptide from renal elimination and peptidases.

That chemistry is the molecule's reason for being. Unconjugated GHRH fragments are cleared within minutes, whereas the albumin-linked form has been reported to last for days in animal models, giving continuous instead of pulsed receptor exposure. Researchers therefore deploy it as a long-acting comparator to separate out the effects of sustained GHRH receptor occupancy on somatotroph signalling, receptor desensitisation and downstream IGF-1.

## Frequently asked questions

### What does “DAC” stand for?

Drug affinity complex: the maleimidopropionyl group on the C-terminal lysine, which reacts with cysteine-34 of serum albumin. The covalent bond formed shields the peptide from clearance and greatly prolongs how long it remains in circulation in animal models.

### Which buffers must I avoid when reconstituting?

Do not use solvents that contain free thiols or reducing agents — DTT, TCEP, beta-mercaptoethanol and the like. They react with the maleimide and wipe out the albumin-binding function. Bacteriostatic or sterile water is the normal lab choice.

### Can I get a Certificate of Analysis?

Yes. An independent laboratory tests every lot by HPLC for identity and ≥99% purity, and the certificate for your lot can be requested. Check that the lot number on the vial corresponds to the certificate before logging the material in your inventory.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/cjc-1295-dac/