# Decapeptide-12 (Lumixyl-type)

> Tyrosinase-inhibiting 10-amino-acid peptide for melanogenesis research

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/decapeptide-12/
- Brand: Peptide Medix EU
- Category: [Cosmetic Signal Peptides](https://peptidemedixeu.com/en/collections/cosmetic-peptides/)
- Purity: ≥98% by HPLC; lot-matched COA available
- from €63 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 10 mg | €63 | DECAPEPTIDE-12-10-MG |
| 50 mg | €182 | DECAPEPTIDE-12-50-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **Amino acid sequence:** Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr
- **Chain length:** 10 amino acids (decapeptide)
- **Peptide class:** Synthetic cosmetic decapeptide, enzyme-inhibitor type
- **Form:** Lyophilized white to off-white powder, sealed glass vial
- **Purity:** ≥98% by HPLC; lot-matched COA available
- **Available sizes:** 10 mg, 50 mg
- **Solubility:** Water-soluble; solutions are commonly buffered near neutral pH for enzyme assays
- **Storage (lyophilized):** −20 °C, sealed and protected from light and moisture
- **Storage (reconstituted):** 2–8 °C, protected from light, used within the study window
- **INCI name:** Decapeptide-12
- **Also known as:** Lumixyl peptide; oligopeptide tyrosinase inhibitor
- **Molecular target:** Tyrosinase, the rate-limiting enzyme of melanin biosynthesis
- **Notable residues:** Three tyrosines and one tryptophan — aromatic and light-sensitive; two arginines and a lysine give a net positive charge at neutral pH
- **Research areas:** Melanogenesis, tyrosinase inhibition kinetics, pigmentation models, comparative depigmenting agent studies, peptide skin permeation

## Description

Decapeptide-12 is a synthetic peptide of ten residues — Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr — discovered by screening combinatorial peptide libraries for sequences that bind to and inhibit tyrosinase. It is the active ingredient of Lumixyl-type cosmetic systems and carries the INCI name Decapeptide-12. Peptide Medix EU sells it as lyophilised research powder in 10 mg and 50 mg vials, not as a finished cosmetic.

Tyrosinase controls the pace of melanin production: it hydroxylates L-tyrosine to L-DOPA and then oxidises that to dopaquinone. Most small-molecule inhibitors in this area — hydroquinone, kojic acid, arbutin — either mimic the substrate or bind the enzyme's two-copper active site. A peptide inhibitor works differently, engaging the enzyme surface through a defined sequence, and as a peptide it also differs from those small molecules in stability and skin-permeation behaviour.

## Frequently asked questions

### Is it the peptide found in Lumixyl products?

Yes, the sequence is the same — the INCI-listed Decapeptide-12 on which those systems are based. We supply only the raw lyophilised peptide in a research vial, not a formulation, so there is no cosmetic base, preservative or other active ingredient.

### What is its proposed mechanism?

The literature describes it as a tyrosinase inhibitor — tyrosinase being the rate-limiting enzyme that turns L-tyrosine into melanin precursors. It emerged from peptide-library screens for sequences that engage this enzyme, and studies typically measure enzyme activity and melanin content in cell models.

### Which purity documents are included?

Every lot is HPLC-tested to ≥98% and comes with its own certificate of analysis, including mass-spectrometric confirmation of the ten-residue sequence. Please quote the lot number printed on your vial when asking for it.

### Why keep the vial away from light?

With one tryptophan and three tyrosines, the sequence contains aromatic side chains that photo-oxidise readily. Light can therefore degrade the peptide and change the activity you measure, so keep both the powder and any solution in the dark.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/decapeptide-12/