# Dihexa

> Peptidomimetic derived from angiotensin IV, studied in HGF/c-Met synapse-formation models

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/dihexa/
- Brand: Peptide Medix EU
- Category: [Nootropic Peptides](https://peptidemedixeu.com/en/collections/nootropic-peptides/)
- Purity: ≥99% by HPLC; lot-matched COA available
- CAS number: 1401708-83-5
- from €140 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 10 mg | €140 | DIHEXA-10-MG |
| 20 mg | €250 | DIHEXA-20-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 1401708-83-5
- **Form:** Lyophilized powder in a sealed glass vial
- **Purity:** ≥99% by HPLC; lot-matched COA available
- **Available sizes:** 10 mg, 20 mg
- **Solubility:** Poorly water-soluble; a co-solvent such as DMSO is commonly used before dilution
- **Storage (lyophilized):** −20 °C, protected from light and moisture
- **Chemical name:** N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide
- **Compound class:** Angiotensin IV-derived peptidomimetic (dipeptide core with lipophilic termini)
- **Primary research target:** HGF / c-Met receptor signaling
- **Research areas:** Synaptogenesis, dendritic spine density, hippocampal culture models, cognitive impairment models
- **Synthesis:** Solid-phase synthesis with preparative HPLC purification
- **Storage (in solution):** 2–8 °C short term; −20 °C in aliquots for longer storage

## Description

Dihexa is a compact synthetic peptidomimetic that grew out of angiotensin IV research at Washington State University. Its full name, N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide, spells out the design: a two-amino-acid core capped by a hexanoyl chain on one side and an aminohexanoic amide on the other. Those unusual, fat-loving end groups are intentional — they make the molecule resistant to metabolism and much more lipid-soluble than an ordinary short peptide.

Research on it revolves around hepatocyte growth factor and its receptor, c-Met, which leads to assays such as dendritic spine counts and synaptic markers in hippocampal cultures, electrophysiological measures of synaptic strength and rodent models of cognitive decline. Since different sources publish conflicting formula and mass values, the certificate for your lot — not a database record — is what documents the vial's contents. Preparation is the other practical hurdle: the same hexanoyl and aminohexanoic ends that confer stability make the compound poorly soluble in water, so make a concentrated DMSO stock first, check for precipitate at the working dilution and keep solvent levels within what the assay tolerates. Available in 10 mg and 20 mg vials.

## Frequently asked questions

### Is Dihexa a true peptide?

Not in the usual sense. It is a peptidomimetic: a two-residue core with a hexanoyl group and an aminohexanoic amide at its ends. Those non-amino-acid parts make it protease-resistant and very lipophilic, so it acts more like a small drug molecule than a typical research peptide.

### Why is a co-solvent needed?

The lipophilic end groups that stabilise Dihexa also make it dissolve poorly in water. Most labs first dissolve it in a suitable organic solvent such as DMSO, then dilute into buffer, confirming there is no precipitate at the concentration used in the assay.

### What documentation confirms purity?

We analyse each lot by HPLC for purity and by mass spectrometry for identity, and the lot's certificate is available on request. Given that published formula and mass data for Dihexa vary between sources, the COA is the definitive record of what you receive.

### Which sizes are available?

10 mg and 20 mg lyophilised vials. Because most labs work from a co-solvent stock, the larger vial makes it easier to run a long series from one lot and one stock preparation.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/dihexa/