# DSIP (Delta Sleep-Inducing Peptide)

> Nonapeptide researched in sleep architecture, stress and neuroendocrine studies

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/dsip/
- Brand: Peptide Medix EU
- Category: [Sleep & Stress Peptides](https://peptidemedixeu.com/en/collections/sleep-peptides/)
- Purity: ≥99% by HPLC; lot-matched COA available
- CAS number: 62568-57-4
- from €55 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 5 mg | €55 | DSIP-5-MG |
| 10 mg | €97 | DSIP-10-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 62568-57-4
- **Molecular formula:** C35H48N10O15
- **Molecular weight:** 848.81 g/mol
- **Amino acid sequence:** Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE)
- **Peptide class:** Endogenous nonapeptide (delta sleep-inducing peptide)
- **Form:** Lyophilized white powder in a sealed glass vial
- **Purity:** ≥99% by HPLC; lot-matched COA available
- **Available sizes:** 5 mg, 10 mg
- **Solubility:** Soluble in bacteriostatic water and sterile water
- **Storage (lyophilized):** −20 °C, protected from light and moisture
- **Storage (reconstituted):** 2–8 °C; aliquot to avoid repeated freeze-thaw
- **Research areas:** EEG delta activity, sleep architecture, stress and corticotropin studies, thermoregulation, withdrawal models
- **Stability note:** Short plasma half-life reported; keep solutions cold and freshly prepared

## Description

DSIP (delta sleep-inducing peptide) is a nine-residue peptide — Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu — with a molecular weight of 848.81 g/mol. Schoenenberger and Monnier first isolated it in the 1970s from the cerebral venous blood of rabbits kept in electrically induced delta-wave sleep, which is where both its name and its long-standing link to sleep-architecture research come from.

Research on this nonapeptide includes EEG recording of delta activity and sleep-architecture analysis, work on corticotropin and the stress axis, thermoregulation and withdrawal models — much of it European and concentrated in the twenty years after its discovery. Interpreting results has always been complicated by the short plasma persistence reported for DSIP. That fragility affects day-to-day handling more than a storage table implies: keep solutions at 2–8 °C, divide them into aliquots instead of thawing repeatedly, and prepare them shortly before use, since the aspartate-glycine pair and the N-terminal tryptophan both give the peptide easy ways to degrade in water. Vials come in 5 mg and 10 mg; multi-arm studies usually opt for the larger size so that the entire study uses one lot number.

## Frequently asked questions

### What does the abbreviation DSIP mean?

Delta sleep-inducing peptide. The name recalls how it was found: in the 1970s scientists extracted it from rabbit cerebral venous blood during electrically triggered delta-wave sleep, and that association has guided its research ever since.

### Is DSIP tested by an independent laboratory?

Yes. Each lot's purity is measured by reversed-phase HPLC and its identity verified by mass spectrometry; on request you receive the certificate for your batch, stating purity, observed mass and date of analysis.

### Which vial sizes can I choose?

5 mg and 10 mg lyophilised vials. Studies with multiple time points or arms typically choose 10 mg, so the complete series runs on a single lot number and a single certificate.

### How should I handle DSIP after reconstitution?

Keep it cold (2–8 °C) and dark, and make working dilutions just before you need them. Because the peptide is reported to be short-lived in biological fluids, cold handling and single-use aliquots are routine, not optional extras.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/dsip/