# Ecnoglutide

> Research-grade long-acting GLP-1 receptor agonist with cAMP-biased signalling (XW003)

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/ecnoglutide/
- Brand: Peptide Medix EU
- Category: [GLP-1 & Incretin Peptides](https://peptidemedixeu.com/en/collections/glp-1-peptides/)
- Purity: ≥99% by HPLC; lot-matched COA available
- from €97 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 5 mg | €97 | ECNOGLUTIDE-5-MG |
| 10 mg | €170 | ECNOGLUTIDE-10-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **Form:** Lyophilized powder in a sealed glass vial with flip-off cap
- **Purity:** ≥99% by HPLC; lot-matched COA available
- **Available sizes:** 5 mg, 10 mg
- **Solubility:** Bacteriostatic water; also soluble in dilute alkaline or phosphate buffers
- **Storage (lyophilized):** −20 °C, sealed and protected from light and moisture
- **Storage (reconstituted):** 2–8 °C, protected from light; use within the study window
- **Research code:** XW003
- **Compound class:** Acylated long-acting GLP-1 receptor agonist analogue (incretin mimetic)
- **Receptor target:** Glucagon-like peptide-1 receptor (GLP-1R), a class B GPCR
- **Signalling profile:** Reported as cAMP-biased, with reduced beta-arrestin recruitment relative to balanced agonists
- **Design features:** DPP-4-resistant backbone modification plus a fatty-acid side chain for albumin association
- **Research areas:** Biased GLP-1R agonism, receptor internalisation and desensitisation, glucose handling and appetite models
- **Regulatory status:** Investigational; not approved by the FDA for any indication

## Description

Ecnoglutide — XW003 in development papers — is a long-acting analogue that activates the glucagon-like peptide-1 receptor. As with others in its class, it is built on the GLP-1 sequence with changes that protect it from dipeptidyl peptidase-4 and a fatty side chain that encourages albumin binding, which together keep it in circulation far longer than native GLP-1. What sets it apart in the published descriptions is how it signals: it is characterised as cAMP-biased, favouring Gs-coupled cAMP production over beta-arrestin recruitment at the receptor.

Ecnoglutide is supplied as lyophilised powder in sealed 5 mg and 10 mg vials, HPLC-purified to ≥99% and released with a certificate of analysis for the lot. It is dispatched from our EU warehouse and sold exclusively for laboratory research.

## Frequently asked questions

### What is ecnoglutide?

A long-acting GLP-1 receptor agonist analogue with the research code XW003. It carries the class's typical backbone changes and fatty-acid acylation, and published work describes it as preferring cAMP signalling at the receptor.

### How does it compare with semaglutide?

Both are acylated single agonists at GLP-1R, yet ecnoglutide is reported to favour Gs/cAMP signalling while recruiting less beta-arrestin. Comparative assays exploit this to separate the effects of signalling bias from those of receptor coverage.

### What purity and documents come with it?

Every lot is HPLC-purified to ≥99% and released with its own certificate of analysis for purity and identity. Tell us the lot number on your vial and we will send the matching COA.

### How is reconstituted ecnoglutide stored?

At 2–8 °C, protected from light, for no longer than your protocol allows. Divide it into aliquots before freezing at −20 °C to spare it the freeze–thaw cycles that damage acylated peptides most quickly.

### Can I purchase ecnoglutide for personal use?

No. It is a research chemical, sold only for use in the laboratory.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/ecnoglutide/