# FOXO4-DRI

> D-retro-inverso FOXO4-derived peptide used as a senolytic research tool

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/foxo4-dri/
- Brand: Peptide Medix EU
- Category: [Telomere & Senolytic Peptides](https://peptidemedixeu.com/en/collections/telomere-senolytic-peptides/)
- Purity: ≥99% by HPLC; lot-matched COA
- CAS number: 2114879-72-6
- from €182 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 10 mg | €182 | FOXO4-DRI-10-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 2114879-72-6
- **Molecular weight:** ≈6053 g/mol (see lot COA for exact value)
- **Peptide class:** Cell-penetrating senolytic peptide
- **Form:** Lyophilized powder, sealed glass vial
- **Purity:** ≥99% by HPLC; lot-matched COA
- **Solubility:** Water or bacteriostatic water; sterile-filter before cell work
- **Storage (lyophilized):** −20 °C, protected from light and moisture
- **Storage (reconstituted):** 2–8 °C for short-term use; aliquot and freeze for longer studies
- **Available size:** 10 mg
- **Chirality:** All-D amino acids, retro-inverso orientation
- **Parent protein:** FOXO4 forkhead box O transcription factor
- **Research areas:** Cellular senescence, FOXO4–p53 interaction, senolytics, SASP markers

## Description

FOXO4-DRI is a synthetic peptide derived from part of the FOXO4 transcription factor and redesigned in D-retro-inverso form: its sequence runs backwards and every amino acid is the D-enantiomer, which roughly preserves the side-chain arrangement of the original L-peptide while making it far less vulnerable to proteases. A cell-penetrating stretch is built in so the peptide can reach intracellular targets in cultured cells.

It comes as lyophilised powder in a sealed vial, with analytical documentation for the lot. Being a long and strongly charged peptide, it calls for careful planning of reconstitution and storage.

## Frequently asked questions

### What is FOXO4-DRI?

A synthetic D-retro-inverso peptide based on the FOXO4 transcription factor, used in the lab as a senolytic tool that disrupts the FOXO4–p53 interaction reported in senescent cells.

### What does “D-retro-inverso” mean?

The sequence is reversed and made entirely of D-amino acids instead of the natural L-forms. This keeps the side chains in approximately the same spatial arrangement while giving a protease-resistant backbone, so the peptide lasts longer in experiments.

### Is the lot tested by an independent lab?

Yes. HPLC is used to determine purity and mass spectrometry to confirm identity for every lot, and the Certificate of Analysis can be viewed before you buy. Use the net peptide content stated on the COA when you calculate working concentrations.

### Which size can I buy?

A single 10 mg lyophilised vial. At about 6053 g/mol, this peptide is so heavy that 10 mg equals far fewer moles than 10 mg of a short peptide like epitalon.

### How do I reconstitute it?

Use sterile or bacteriostatic water, adding it gently down the inside of the vial and swirling rather than shaking. As the peptide is long and charged, give it extra time to dissolve and use low-binding labware to limit losses by adsorption.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/foxo4-dri/