# Gonadorelin

> Synthetic GnRH — the unmodified hypothalamic decapeptide

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/gonadorelin/
- Brand: Peptide Medix EU
- Category: [Hormonal & Fertility Peptides](https://peptidemedixeu.com/en/collections/hormonal-fertility-peptides/)
- Purity: ≥99% by HPLC; lot-matched COA
- CAS number: 33515-09-2
- from €38 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 2 mg | €38 | GONADORELIN-2-MG |
| 5 mg | €63 | GONADORELIN-5-MG |
| 10 mg | €97 | GONADORELIN-10-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 33515-09-2
- **Molecular formula:** C55H75N17O13
- **Molecular weight:** 1182.29 g/mol
- **Amino acid sequence:** pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
- **Peptide class:** Linear amidated decapeptide; hypothalamic releasing hormone
- **Form:** Lyophilized white powder, sealed glass vial
- **Purity:** ≥99% by HPLC; lot-matched COA
- **Available sizes:** 2 mg, 5 mg, 10 mg
- **Solubility:** Soluble in water and bacteriostatic water; dilute acetic acid assists difficult lots
- **Storage (lyophilized):** −20 °C, desiccated and protected from light
- **Storage (reconstituted):** 2–8 °C for short-term use; aliquot and freeze for longer holds
- **Receptor target:** GnRH receptor (GnRHR) on pituitary gonadotrophs, Gq/11-coupled
- **Research areas:** HPG-axis regulation, pulsatile versus continuous receptor signalling, gonadotroph physiology

## Description

Gonadorelin is synthetic gonadotropin-releasing hormone in its native form — the decapeptide itself rather than an analogue. Its sequence, pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, matches the hypothalamic hormone isolated and characterised by Schally and Guillemin, whose work earned the 1977 Nobel Prize. An N-terminal pyroglutamate and a C-terminal amide shield it against exopeptidases, yet it is still eliminated rapidly, with a half-life in the circulation of only minutes.

In research that short half-life is an asset, not a flaw. Hypothalamic neurons release GnRH in discrete bursts, and pituitary gonadotrophs respond to that rhythm rather than to the average level. Pulsed stimulation keeps luteinising hormone and follicle-stimulating hormone flowing, while constant exposure downregulates and desensitises the GnRH receptor and eventually shuts gonadotropin release down. Because gonadorelin is cleared so quickly, it is the obvious tool for mimicking physiological pulsatility — the opposite of long-acting analogues like triptorelin.

## Frequently asked questions

### Are gonadorelin and GnRH identical?

Yes. Gonadorelin is synthetic gonadotropin-releasing hormone with the natural, unmodified decapeptide sequence. Analogues such as triptorelin or leuprolide contain substitutions that prolong their half-life; gonadorelin has none, so it disappears within minutes and behaves differently in experiments.

### Why does pulsed versus continuous exposure make such a difference?

Gonadotrophs respond to the timing pattern of GnRH, not merely its level. Intermittent pulses maintain LH and FSH secretion, whereas continuous exposure downregulates and desensitises the receptor and suppresses release. Most experimental designs in this field are built around that distinction.

### How does it compare with Kisspeptin-10?

They work at different points of one axis. Kisspeptin-10 activates GnRH neurons through KISS1R, a step further upstream, while gonadorelin acts straight on pituitary GnRH receptors. Using both helps researchers pinpoint where in the cascade an effect arises.

### Do you provide a certificate of analysis?

Yes. Each lot is characterised by reverse-phase HPLC (≥99% purity) and mass spectrometry (identity), and the COA for your lot can be requested. The batch number on the vial matches the document, so results remain traceable to a defined analysis.

### Which vial sizes are available?

2 mg, 5 mg and 10 mg. Since receptor assays generally use low working concentrations, the 2 mg vial is enough for many studies; the larger sizes suit long series in which keeping one lot throughout eliminates batch variability.

### How do I reconstitute and store it?

Add sterile or bacteriostatic water slowly down the side of the vial and swirl gently. Store unopened vials at −20 °C, dry and dark. Reconstituted solution is fine at 2–8 °C for short-term use; for longer periods, aliquot and freeze so it is not thawed repeatedly.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/gonadorelin/