# Humanin

> Mitochondrial-derived 24-amino-acid peptide researched for cytoprotective signalling

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/humanin/
- Brand: Peptide Medix EU
- Category: [Mitochondrial Peptides](https://peptidemedixeu.com/en/collections/mitochondrial-peptides/)
- Purity: ≥99% by HPLC; lot-matched COA
- CAS number: 330936-69-1
- from €85 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 5 mg | €85 | HUMANIN-5-MG |
| 10 mg | €153 | HUMANIN-10-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 330936-69-1
- **Molecular formula:** C119H204N34O32S2
- **Molecular weight:** 2687.27 g/mol
- **Amino acid sequence:** Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
- **Peptide class:** Mitochondrial-derived peptide (MDP)
- **Form:** Lyophilized powder, sealed glass vial
- **Purity:** ≥99% by HPLC; lot-matched COA
- **Available sizes:** 5 mg, 10 mg
- **Solubility:** Bacteriostatic or sterile water; may require gentle warming
- **Storage (lyophilized):** −20 °C, protected from light and moisture
- **Storage (reconstituted):** 2–8 °C, used within the study window
- **Gene of origin:** MT-RNR2 (mitochondrial 16S rRNA region)
- **Research areas:** Cytoprotection, apoptosis signaling, neuronal survival models, metabolic and endothelial research

## Description

Humanin is a peptide of 24 amino acids encoded inside the mitochondrial 16S rRNA gene (MT-RNR2), and it was the first mitochondrial-derived peptide ever characterised. It was found in 2001 while screening neurons that had survived in a sample from the occipital lobe — which is why its name points to that survival phenotype and not to any chemical feature.

We make humanin by solid-phase peptide synthesis, purify it by HPLC and lyophilise it into sealed vials. Purity and identity are verified for every lot, and the Certificate of Analysis can be viewed before you buy. For laboratory research only.

## Frequently asked questions

### What is humanin?

A 24-residue peptide encoded in the mitochondrial 16S rRNA gene — the first mitochondrial-derived peptide to be discovered. It is investigated in lab models of cell survival, apoptotic signalling and metabolic control.

### Is this humanin tested by an independent lab?

Yes. HPLC confirms ≥99% purity and mass spectrometry confirms identity for every lot, and you can view the lot's Certificate of Analysis on this page before buying to compare the data with your own acceptance criteria.

### What distinguishes humanin from MOTS-c?

Both come from mitochondrial DNA, but from different regions, and they differ in sequence and length. Humanin has 24 residues and is encoded in the 16S rRNA gene; MOTS-c has 16 residues from the 12S region, and their reported signalling differs as well.

### Why does my humanin dissolve slowly?

Its sequence contains a hydrophobic, leucine-rich core, so it goes into solution more slowly than short hydrophilic peptides. Add the diluent gently, swirl for several minutes and, if necessary, warm it to about 25–30 °C instead of shaking the vial.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/humanin/