# Ipamorelin

> Selective GHS-R1a pentapeptide agonist, Aib-His-D-2-Nal-D-Phe-Lys-NH2

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/ipamorelin/
- Brand: Peptide Medix EU
- Category: [GHRPs & Secretagogues](https://peptidemedixeu.com/en/collections/ghrp-peptides/)
- Purity: ≥99% by HPLC; lot-matched COA available
- CAS number: 170851-70-4
- from €34 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 2 mg | €34 | IPAMORELIN-2-MG |
| 5 mg | €42 | IPAMORELIN-5-MG |
| 10 mg | €63 | IPAMORELIN-10-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 170851-70-4
- **Molecular formula:** C38H49N9O5
- **Molecular weight:** 711.85 g/mol
- **Amino acid sequence:** Aib-His-D-2-Nal-D-Phe-Lys-NH2
- **Chain length:** 5 residues, C-terminal amide
- **Peptide class:** Growth hormone releasing peptide (GHRP), GHS-R1a agonist
- **Form:** Lyophilized powder, sealed glass vial
- **Purity:** ≥99% by HPLC; lot-matched COA available
- **Available sizes:** 2 mg, 5 mg, 10 mg
- **Storage (lyophilized):** −20 °C, sealed and protected from light and moisture
- **Unnatural residues:** Aib (2-aminoisobutyric acid), D-2-naphthylalanine, D-phenylalanine
- **Primary target:** Growth hormone secretagogue receptor 1a (ghrelin receptor)
- **Research areas:** GHS-R1a signalling, secretagogue selectivity, gastrointestinal motility models

## Description

Ipamorelin is a five-residue synthetic peptide designed to activate selectively the growth hormone secretagogue receptor GHS-R1a — the receptor of the natural hormone ghrelin. Its sequence, Aib-His-D-2-Nal-D-Phe-Lys-NH2, squeezes a non-natural aminoisobutyric acid, two D-amino acids and a C-terminal amide into five positions, producing a compact molecule of roughly 712 g/mol that ordinary proteases struggle to break down.

Ipamorelin stood out in the peptide literature because of how selective it is. Older secretagogues like GHRP-6 and hexarelin were found to shift cortisol, prolactin and appetite signalling as well, whereas ipamorelin gave a comparatively clean growth hormone response in animal models. That is why it became a standard tool for isolating GHS-R1a signalling from the wider neuroendocrine background.

## Frequently asked questions

### What is ipamorelin?

A synthetic five-amino-acid agonist of GHS-R1a, the growth hormone secretagogue receptor that ghrelin normally activates. Labs use it as a selective reference compound to study secretagogue signalling independently of the GHRH pathway.

### What makes ipamorelin “selective”?

In comparative animal work it released growth hormone without the accompanying shifts in cortisol, ACTH and prolactin seen with GHRP-6 and hexarelin. This narrower profile lets researchers credit their observations to GHS-R1a activation instead of broad neuroendocrine stimulation.

### How is it different from a GHRH analogue?

Ipamorelin works on the ghrelin receptor GHS-R1a, which couples to Gq and triggers calcium signalling; sermorelin and CJC-1295 act on the Gs-coupled GHRH receptor and raise cyclic AMP. Because these are separate pathways, combination experiments are common in vitro.

### Is its purity independently verified?

Yes. An independent lab confirms identity and ≥99% purity by HPLC for each lot, and the matching Certificate of Analysis is available on request. Compare the vial's lot number with the certificate when entering it into your inventory.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/ipamorelin/