# Kisspeptin-10

> KISS1-derived decapeptide agonist of the KISS1R (GPR54) receptor

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/kisspeptin-10/
- Brand: Peptide Medix EU
- Category: [Hormonal & Fertility Peptides](https://peptidemedixeu.com/en/collections/hormonal-fertility-peptides/)
- Purity: ≥99% by HPLC; lot-matched COA
- CAS number: 374675-21-5
- from €42 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 5 mg | €42 | KISSPEPTIN-10-5-MG |
| 10 mg | €63 | KISSPEPTIN-10-10-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 374675-21-5
- **Molecular formula:** C63H83N17O14
- **Molecular weight:** 1302.47 g/mol
- **Amino acid sequence:** Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
- **Peptide class:** Linear amidated decapeptide; RFamide-related peptide
- **Form:** Lyophilized white to off-white powder, sealed glass vial
- **Purity:** ≥99% by HPLC; lot-matched COA
- **Available sizes:** 5 mg, 10 mg
- **Solubility:** Soluble in water and bacteriostatic water; dilute acetic acid or DMSO aids stubborn lots
- **Storage (lyophilized):** −20 °C, desiccated and protected from light
- **Storage (reconstituted):** 2–8 °C for immediate use; aliquot at −20 °C or below for longer holds
- **Receptor target:** KISS1R (GPR54), a Gq/11-coupled class A GPCR
- **Research areas:** GnRH pulse generation, HPG-axis regulation, puberty onset models, metastasis suppression

## Description

Kisspeptin-10 consists of the last ten residues at the C-terminus of kisspeptin-54, which the KISS1 gene encodes. It is the shortest sequence that keeps full activity at KISS1R — the G-protein-coupled receptor first listed as GPR54 — and both its C-terminal amide and the final Arg-Phe motif are indispensable for binding. KISS1 was originally discovered by cancer researchers as a suppressor of metastasis, hence the family's alternative name metastin, long before its role in reproductive neuroendocrinology emerged.

Two properties of this decapeptide determine how it should be handled. It finishes with the Arg-Phe-NH2 motif that defines the RFamide family, and the receptor needs that amide, so losing it is a degradation pathway to keep in mind during long incubations; it also contains a tryptophan, which is prone to oxidation and light damage. Keep vials dry at −20 °C and aliquot solutions rather than thawing them repeatedly; if a lot resists dissolving, a little dilute acetic acid or DMSO can help before dilution into buffer. Research focuses on reproductive neuroendocrinology — GnRH pulse generation in hypothalamic preparations, gonadotropin responses in rodents, onset of puberty — with a continuing line of work on the parent gene's role in suppressing metastasis.

## Frequently asked questions

### How are Kisspeptin-10 and kisspeptin-54 related?

Kisspeptin-10 is the final ten amino acids of kisspeptin-54, the complete KISS1 gene product. It keeps practically all of the activity at KISS1R, making it the convenient tool compound, though it is cleared faster than its longer parent — a difference researchers often use on purpose.

### Which receptor does it activate?

KISS1R, once known as the orphan receptor GPR54 — a class A GPCR coupled to Gq/11 and abundant on GnRH neurons. This puts kisspeptin signalling immediately upstream of the hypothalamic–pituitary–gonadal axis in the models that study it.

### Is its purity independently confirmed?

Yes. Reverse-phase HPLC shows ≥99% purity and mass spectrometry confirms identity for every lot, and you can request the lot's certificate. The vial's batch number matches the COA, so your measurements trace back to a defined analysis.

### How does it compare with gonadorelin or triptorelin?

Kisspeptin-10 works one level higher up the axis: it stimulates GnRH neurons, whereas gonadorelin is GnRH itself and triptorelin a GnRH analogue, both acting directly at pituitary GnRH receptors. That hierarchy is why all three are often included in one study.

### Which sizes are available, and how are they stored?

Lyophilised vials of 5 mg and 10 mg. Keep sealed vials at −20 °C, dry and away from light. Once reconstituted, store at 2–8 °C for short-term use, or aliquot and freeze, avoiding repeated freeze–thaw cycles.

### Why would a metastasis-suppressor gene matter for reproduction?

KISS1 got its name from cancer biology before human genetic studies revealed its receptor's reproductive role. Both functions are real: the same peptide–receptor pair works in different tissue contexts, and both fields use Kisspeptin-10 as their reference agonist.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/kisspeptin-10/