# Liraglutide

> Research-grade GLP-1 receptor agonist analogue: 31 residues with a palmitoyl chain

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/liraglutide/
- Brand: Peptide Medix EU
- Category: [GLP-1 & Incretin Peptides](https://peptidemedixeu.com/en/collections/glp-1-peptides/)
- Purity: ≥99% by HPLC; lot-matched COA available
- CAS number: 204656-20-2
- from €55 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 5 mg | €55 | LIRAGLUTIDE-5-MG |
| 10 mg | €97 | LIRAGLUTIDE-10-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 204656-20-2
- **Molecular formula:** C172H265N43O51
- **Molecular weight:** 3751.20 g/mol
- **Amino acid sequence:** His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(gamma-Glu-palmitoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly
- **Peptide class:** Acylated GLP-1 receptor agonist analog (incretin mimetic)
- **Form:** Lyophilized powder, sealed glass vial with flip-off seal
- **Purity:** ≥99% by HPLC; lot-matched COA available
- **Available sizes:** 5 mg, 10 mg
- **Storage (lyophilized):** −20 °C, sealed and protected from light and moisture
- **Storage (reconstituted):** 2–8 °C, protected from light; use within the study window
- **Backbone length:** 31 amino acids, based on GLP-1(7-37)
- **Research areas:** GLP-1 receptor signaling, insulin secretion, appetite and gastric-emptying models

## Description

Liraglutide earned its place in history by showing that attaching a lipid could make a fragile incretin into a long-lasting tool compound, and incretin research still leans on it as a reference. Labs deploy it as the benchmark GLP-1 receptor agonist in cyclic-AMP and beta-arrestin assays, in islet and beta-cell secretion experiments and in rodent feeding models — especially when an established single agonist needs to be set against newer diacid-acylated or multi-receptor peptides.

Its structure is GLP-1(7-37) with two modifications. Arginine replaces lysine 34, so only one lysine remains, and that Lys26 bears a gamma-glutamyl linker carrying a C16 palmitoyl group. The swap is as important as the acylation itself, because it ensures the fatty acid goes to a single position instead of two. The acyl chain promotes reversible binding to albumin and self-assembly into oligomers — behaviour that has made liraglutide a standard model in biophysical research on lipidated peptides. It dissolves in bacteriostatic water, though more slowly than unmodified peptides, so run the solvent down the glass and be patient. Vials hold 5 mg or 10 mg; molecular weight 3751.20 g/mol.

## Frequently asked questions

### What distinguishes liraglutide from semaglutide?

Both are acylated GLP-1 receptor agonist analogues. Liraglutide has a C16 palmitoyl chain and no Aib, so it persists in circulation for less time; semaglutide combines Aib at position 2 with a C18 diacid, which greatly lengthens its half-life in published pharmacokinetic studies.

### Why do researchers still use liraglutide?

Few GLP-1 agonists have been characterised as thoroughly, which makes it a reliable reference arm. Its tendency to self-associate also makes it a handy model for biophysical work on lipidated peptides.

### Which purity data and documents come with it?

Each lot is HPLC-tested to ≥99% and its identity confirmed by mass spectrometry. The certificate for the lot, keyed to the vial number you receive, is available so results can be traced to the exact material.

### Is it easy to dissolve?

It goes into bacteriostatic water, but the palmitoyl chain makes it slower to clear than plain peptides. Add solvent gently along the vial wall, swirl and give it time; some labs use a slightly alkaline buffer to help before adjusting to assay conditions.

### What are the storage requirements?

Store the unopened lyophilised vial at −20 °C, away from light and humidity. After reconstitution, refrigerate at 2–8 °C in the dark and finish it within your documented study period, aliquoting so the stock isn't frozen and thawed repeatedly.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/liraglutide/