# Melatonin Nasal Spray

> Ready-mixed melatonin research solution for intranasal studies, metered pump bottles

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/melatonin-nasal-spray/
- Brand: Peptide Medix EU
- Category: [Nasal Peptide Sprays](https://peptidemedixeu.com/en/collections/nasal-peptide-sprays/)
- CAS number: 73-31-4
- from €46 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 15 mL | €46 | MELATONIN-NASAL-SPRAY-15-ML |
| 30 mL | €76 | MELATONIN-NASAL-SPRAY-30-ML |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 73-31-4
- **Molecular formula:** C13H16N2O2
- **Molecular weight:** 232.28 g/mol
- **Form:** Pre-mixed aqueous solution in a bottle fitted with a metered spray pump
- **Available sizes:** 15 mL and 30 mL fill volumes
- **Concentration:** Printed on the bottle label and restated on the lot-matched COA
- **Metered pump:** Delivers a fixed volume per actuation, typically around 0.1 mL for nasal pumps of this size
- **Active compound:** Melatonin (N-acetyl-5-methoxytryptamine)
- **Compound class:** Indoleamine neurohormone (small molecule, not a peptide)
- **Receptor targets:** MT1 and MT2 G-protein-coupled melatonin receptors
- **Reconstitution:** None required — supplied pre-mixed and ready to dispense
- **Research areas:** Circadian biology, pineal signalling, sleep-model pharmacology, intranasal and route-comparison studies
- **Storage:** 2–8 °C, upright and protected from light; do not freeze the filled bottle
- **Stability note:** Melatonin in solution photodegrades — keep in the original light-protected bottle

## Description

This is a ready-mixed water-based solution of melatonin (N-acetyl-5-methoxytryptamine, the pineal indoleamine) in a bottle with a metered spray pump. Choose a 15 mL or 30 mL fill — both can be used straight away, with no weighing, reconstitution or solvent work on the bench.

The format exists because, for melatonin, the delivery route is a research topic in itself. Although small and lipophilic, melatonin undergoes heavy first-pass metabolism in the liver when swallowed, so its oral bioavailability is poor and differs widely between individuals. The nasal lining is thin, well supplied with blood and drains without first passing the liver, making intranasal delivery a long-established comparator in pharmacokinetic studies — including those exploring whether the olfactory region offers a path to the central nervous system that skips the systemic circulation.

## Frequently asked questions

### Spray or vial — what's different?

Only the format. The vial holds lyophilised powder you must weigh or dissolve; the spray is a ready-to-use aqueous solution in a metered pump bottle. Use the spray for route comparisons and delivery characterisation, the vial when you need to choose the concentration yourself.

### How concentrated is the solution?

Your bottle's concentration is printed on its label and confirmed on the lot certificate. Record that documented figure with your data instead of assuming a standard strength — fills may vary from one production lot to the next.

### What volume comes out per press?

Pumps of this type usually deliver a fixed volume of about 0.1 mL, but the number to rely on is the one you measure: prime the pump, then weigh several sprays to establish the volume before treating it as a quantitative parameter.

### What is the point of intranasal melatonin research?

Swallowed melatonin is extensively broken down on its first pass through the liver, leaving low and erratic systemic levels. The nose avoids this, which makes it a valuable pharmacokinetic comparator; whether melatonin can travel directly from nose to brain is a further, separate question.

### How is the spray stored?

In the fridge at 2–8 °C, upright and shielded from light — never frozen. Dissolved melatonin breaks down in light, so keep it in its original light-protective bottle for the whole study.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/melatonin-nasal-spray/