# NAD+

> NAD+ coenzyme (nicotinamide adenine dinucleotide) in 500 mg and 1000 mg vials

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/nad-plus/
- Brand: Peptide Medix EU
- Category: [NAD+ & Glutathione](https://peptidemedixeu.com/en/collections/nad-glutathione/)
- Purity: ≥99% by HPLC; lot-matched COA
- CAS number: 53-84-9
- from €38 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 100 mg | €38 | NAD-PLUS-100-MG |
| 500 mg | €102 | NAD-PLUS-500-MG |
| 1000 mg | €212 | NAD-PLUS-1000-MG |
| 5-vial kit · 5 x 500 mg | €450 | NAD-PLUS-5-VIAL-KIT-5-500-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 53-84-9
- **Molecular formula:** C21H27N7O14P2
- **Molecular weight:** 663.43 g/mol
- **Form:** Lyophilized powder, sealed glass vial
- **Purity:** ≥99% by HPLC; lot-matched COA
- **Available sizes:** 100 mg, 500 mg, 1000 mg
- **Solubility:** Freely soluble in water; solutions are acidic and best buffered
- **Storage (lyophilized):** −20 °C, protected from light and moisture
- **Storage (reconstituted):** 2–8 °C, used promptly; NAD+ hydrolyzes at alkaline pH
- **Chemical class:** Dinucleotide coenzyme (free acid form)
- **Also known as:** Nicotinamide adenine dinucleotide, oxidized NAD, DPN
- **Enzyme substrate for:** Sirtuins (SIRT1–7), PARP family, CD38/CD157
- **Research areas:** Cellular redox state, DNA repair signaling, mitochondrial metabolism, aging biology

## Description

NAD+ — nicotinamide adenine dinucleotide in its oxidised form — is a dinucleotide coenzyme, not a peptide. Nicotinamide mononucleotide and adenosine monophosphate are linked through a pyrophosphate bridge, and the resulting molecule is present in every living cell as the main electron carrier of catabolism. Oxidised NAD+ picks up a hydride and becomes NADH; the balance between the two is one of the most frequently measured markers of a cell's redox status.

Our fills are ten to a hundred times larger than a typical peptide vial — 100 mg, 500 mg and 1000 mg, plus a kit of five 500 mg vials — because the relevant enzymes consume the coenzyme rather than just using it catalytically. Sirtuins, PARPs and the CD38 ectoenzymes cleave NAD+ at its glycosidic bond and release nicotinamide, destroying one molecule per turnover. At 663.43 g/mol, 500 mg equals about 754 micromoles, well matched to assays at the micromolar-to-millimolar levels these enzymes need. NAD+ dissolves freely in water, but its solutions are acidic and hydrolyse easily above neutral pH, so buffer them, keep them cold and use them promptly instead of storing them.

## Frequently asked questions

### Would NAD+ be classed as a peptide?

No. It is a dinucleotide coenzyme in which nicotinamide mononucleotide and adenosine monophosphate are joined via a pyrophosphate bridge. We list it with research peptides because labs working on mitochondrial and ageing biology routinely use both.

### NAD+ versus NADH — what's the relationship?

They are the same coenzyme in oxidised and reduced form. During catabolic reactions NAD+ takes up a hydride to become NADH, and their ratio serves as a readout of cellular redox state in metabolic studies.

### Is this NAD+ verified by an independent lab?

Yes. Each lot is HPLC-analysed to ≥99% purity, and you can review the lot's Certificate of Analysis on this page before buying to check identity and purity against your own acceptance criteria.

### What's the right way to handle NAD+ solutions?

Dissolve in water or a suitable buffer, hold the pH at or just below neutral and use the solution quickly. NAD+ hydrolyses in alkaline conditions and degrades when warm, so cold storage, protection from light and aliquoting all help keep it assay-grade.

### How does NAD+ differ from NMN or nicotinamide riboside?

NMN and nicotinamide riboside are precursors that cells turn into NAD+ via the salvage pathway, whereas NAD+ is the finished coenzyme. Whether loading precursors or supplying the coenzyme directly works better is an active area of comparative research.

### Which sizes do you offer?

500 mg and 1000 mg lyophilised vials. Quantities well above typical peptide fills are normal, since enzyme assays and cell culture use the coenzyme at micromolar to millimolar concentrations.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/nad-plus/