# P-21 Nasal Spray

> Ready-mixed spray of the CNTF mimetic P-21 (P021), metered 15 mL or 30 mL bottle

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/p-21-nasal-spray/
- Brand: Peptide Medix EU
- Category: [Nasal Peptide Sprays](https://peptidemedixeu.com/en/collections/nasal-peptide-sprays/)
- CAS number: 1370554-01-0
- from €140 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 15 mL | €140 | P-21-NASAL-SPRAY-15-ML |
| 30 mL | €242 | P-21-NASAL-SPRAY-30-ML |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 1370554-01-0
- **Molecular weight:** 1017.24 g/mol
- **Form:** Pre-mixed solution in a tinted bottle with metered fine-mist spray pump
- **Available sizes:** 15 mL, 30 mL
- **Concentration:** Fixed per lot — stated on the bottle label and lot certificate of analysis
- **Active compound:** P-21 (P021), adamantylated CNTF-derived peptide mimetic
- **Purity (raw material):** ≥99% by HPLC with mass-spectrometric identity confirmation
- **Core structure:** Ac-Asp-Gly-Gly-Leu-Ag-NH2, where Ag denotes an adamantylated glycine residue
- **Parent protein:** Ciliary neurotrophic factor (CNTF)
- **Vehicle:** Buffered aqueous solution with a solubilising co-solvent fraction and preservative
- **Reconstitution:** None required — supplied ready to dispense
- **Research areas:** Adult neurogenesis, BDNF and CREB signalling, tau-pathology models
- **Storage:** 2–8 °C, upright and protected from light; do not freeze the filled bottle

## Description

This is P-21 (P021) as a ready-mixed spray. P-21 is a compact synthetic mimetic derived from the active region of ciliary neurotrophic factor — and not a simple peptide fragment: the CNTF motif was cut down to a short core, the N-terminus acetylated, the C-terminus amidated and an adamantane unit attached, yielding a molecule far more lipophilic and protease-resistant than the original sequence.

That chemistry is the very reason for a spray version. P-21 dissolves poorly in water, so making it up from lyophilised powder involves a co-solvent and careful checks for precipitation at the final dilution — a step that is easy to get wrong. In the filled bottle with its metered atomiser, the solubilisation has already been done and checked, the concentration is fixed for the lot, and each press releases a reproducible volume — valuable when a study needs identical portions across a group.

## Frequently asked questions

### What's the advantage of the spray over the vial?

P-21's adamantane group makes it poorly water-soluble, so starting from powder means a co-solvent step and precipitation checks at the working dilution. The spray comes ready-formulated and verified, with a metered pump delivering a repeatable volume.

### Can I get a certificate of analysis?

Yes. The raw material is HPLC-tested and mass-spectrometry-confirmed before formulation, and the COA for your lot is available on request — particularly relevant for P-21, whose structural identifiers vary between suppliers and reference databases.

### Is any reconstitution needed?

No. The bottle arrives pre-mixed and ready to use: prime the pump into a waste container until the mist is even, then follow your protocol. The receiving lab does no weighing, dissolving or co-solvent preparation.

### What storage does the spray need?

Refrigerate at 2 to 8 °C, upright and in the dark, and never freeze the filled bottle — freezing and thawing could make the compound precipitate, given its solubility. Let it reach room temperature before priming, and keep the in-use period short once opened.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/p-21-nasal-spray/