# Palmitoyl Tetrapeptide-7 (Pal-GQPR)

> Lipidated GQPR peptide for matrix, cytokine and skin-permeation models

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/palmitoyl-tetrapeptide-7/
- Brand: Peptide Medix EU
- Category: [Cosmetic Signal Peptides](https://peptidemedixeu.com/en/collections/cosmetic-peptides/)
- Purity: ≥99% by HPLC; lot-matched COA available
- CAS number: 221227-05-0
- from €199 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 200 mg | €199 | PALMITOYL-TETRAPEPTIDE-7-200-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 221227-05-0
- **Molecular formula:** C34H62N8O7
- **Molecular weight:** 694.91 g/mol
- **Peptide class:** Lipidated tetrapeptide / matrikine-associated cosmetic peptide
- **Form:** Lyophilized amphiphilic peptide powder, sealed glass vial
- **Purity:** ≥99% by HPLC; lot-matched COA available
- **Solubility:** Low water solubility; use a validated co-solvent or surfactant vehicle
- **Available size:** 200 mg
- **Sequence:** Palmitoyl-Gly-Gln-Pro-Arg-OH (Pal-GQPR)
- **Also known as:** Pal-GQPR, Palmitoyl-GQPR, N-Palmitoyl Rigin, Rigin
- **Research areas:** Fibroblast extracellular-matrix output, cytokine markers, UV-stress models, peptide permeation and formulation stability
- **Storage:** −20 °C lyophilized; protect from light and moisture

## Description

Palmitoyl Tetrapeptide-7 (Pal-GQPR) is Gly-Gln-Pro-Arg acylated at the N-terminus with palmitic acid. The GQPR sequence is linked to a fragment of immunoglobulin G, and the 16-carbon chain boosts lipophilicity, changing how the peptide distributes into membranes, emulsions and other lipid-rich systems. The free tetrapeptide is also known as rigin and shares its C-terminal Pro-Arg with tuftsin (Thr-Lys-Pro-Arg), another short immunoglobulin-derived sequence — worth noting, because it means this peptide is not a true matrikine, since matrikines derive from extracellular-matrix proteins, not antibodies.

It is best known as one of the two peptides in Matrixyl 3000-type formulas, paired with Palmitoyl Tripeptide-1. A separate vial allows labs to study Pal-GQPR by itself, quantify it independently and run single-agent controls before interpreting a two-peptide blend. Published studies lean towards formulation, fibroblast, matrix and cytokine-marker models, and independent evidence is thinner than branded mixture claims might imply. Acylation adds about 238 Da of purely hydrophobic mass, so comparing equal weights with the unmodified sequence means comparing unequal numbers of molecules — designs matched by molarity are the meaningful ones.

The 200 mg vial contains lyophilised Pal-GQPR (CAS 221227-05-0, C34H62N8O7, 694.91 g/mol), HPLC-tested with a certificate of analysis for the lot. It is supplied only as laboratory research material, not as a finished cosmetic or medicinal product.

## Frequently asked questions

### Is Palmitoyl Tetrapeptide-7 simply Matrixyl 3000?

No. It is a single defined peptide, Pal-GQPR, whereas Matrixyl 3000-type systems blend it with Palmitoyl Tripeptide-1 in a formulated mixture. This stand-alone vial makes single-agent controls and separate quantification possible.

### What is its sequence?

Gly-Gln-Pro-Arg with a C16 palmitoyl group on the N-terminus — written Pal-GQPR. It is registered as CAS 221227-05-0, molecular weight 694.91 g/mol.

### Why does it dissolve so poorly in water?

The 16-carbon palmitoyl chain presents a large hydrophobic surface. That improves partitioning into lipid phases but also promotes aggregation and sticking to surfaces, so vehicle and labware must be chosen carefully and recorded.

### How does it compare with Palmitoyl Tripeptide-1?

Palmitoyl Tripeptide-1 is built on Gly-His-Lys, Palmitoyl Tetrapeptide-7 on Gly-Gln-Pro-Arg. They carry the same kind of fatty tail but are different sequences addressing different research questions.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/palmitoyl-tetrapeptide-7/