# PE-22-28

> Heptapeptide derived from spadin, researched as a TREK-1 potassium channel blocker

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/pe-22-28/
- Brand: Peptide Medix EU
- Category: [Nootropic Peptides](https://peptidemedixeu.com/en/collections/nootropic-peptides/)
- Purity: ≥99% by HPLC; lot-matched COA available
- CAS number: 1234388-01-0
- from €72 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 10 mg | €72 | PE-22-28-10-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 1234388-01-0
- **Molecular formula:** C35H55N11O9
- **Molecular weight:** 773.89 g/mol
- **Amino acid sequence:** Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR), linear with unmodified termini
- **Peptide class:** Synthetic heptapeptide ion-channel blocker fragment
- **Form:** Lyophilized white powder in a sealed glass vial
- **Purity:** ≥99% by HPLC; lot-matched COA available
- **Solubility:** Soluble in bacteriostatic water and sterile water
- **Storage (lyophilized):** −20 °C, protected from light and moisture
- **Storage (reconstituted):** 2–8 °C; aliquot to avoid repeated freeze-thaw
- **Available size:** 10 mg
- **Primary research target:** TREK-1 (KCNK2) two-pore-domain potassium channel
- **Research areas:** Electrophysiology, mood-related behavioral models, hippocampal neurogenesis and synaptic markers

## Description

PE-22-28 is a synthetic seven-residue peptide matching positions 22–28 of spadin, a peptide cleaved from the propeptide region of sortilin. Spadin drew interest as a natural inhibitor of TREK-1, a two-pore-domain potassium channel that rodent genetic studies have tied to mood regulation. PE-22-28 is the shortened fragment kept after researchers identified which part of spadin was responsible for blocking the channel.

Peptide Medix EU sells PE-22-28 as a 10 mg lyophilised vial for lab research — patch-clamp and receptor assays, analytical method development and authorised animal studies. Every lot is HPLC-purified and identity-confirmed by mass spectrometry, and its certificate of analysis is available on request. Shipped from our EU warehouse. It is a research chemical, not a medicine, supplement or consumer product.

## Frequently asked questions

### Which larger peptide is PE-22-28 taken from?

It matches residues 22 to 28 of spadin, which arises from the propeptide part of sortilin. Researchers pared spadin down to this heptapeptide while pinpointing, in electrophysiology assays, which section carried the TREK-1-blocking activity.

### Has an independent laboratory tested it?

Yes. Reversed-phase HPLC determines purity and mass spectrometry identity for every lot, and the lot certificate — with purity, observed mass and analysis date for the exact batch shipped — is available on request.

### What is TREK-1, and why does it attract research?

TREK-1 is a two-pore-domain background potassium channel encoded by KCNK2. Rodent genetics linked its absence to a mood-related behavioural phenotype, making pharmacological blockade a live research question and spadin-derived fragments useful lab tools.

### How stable is it once dissolved?

As a short linear peptide with unprotected ends, it is more vulnerable to exopeptidases than acetylated or amidated analogues. Refrigerate reconstituted material at 2–8 °C, split it into single-use aliquots and keep working samples cold during assays.

### In what quantity is it supplied?

A single 10 mg lyophilised vial — usually enough for a complete concentration–response series in cell-based electrophysiology, with some left for analytical confirmation.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/pe-22-28/