# Pentosan Polysulfate Sodium

> Semi-synthetic sulfated xylan polysaccharide in 100 mg and 250 mg vials

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/pentosan-polysulfate/
- Brand: Peptide Medix EU
- Category: [Tissue Repair & Healing Peptides](https://peptidemedixeu.com/en/collections/tissue-repair-peptides/)
- Purity: Third-party tested; lot-matched COA available
- CAS number: 37319-17-8
- from €72 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 100 mg | €72 | PENTOSAN-POLYSULFATE-100-MG |
| 250 mg | €140 | PENTOSAN-POLYSULFATE-250-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 37319-17-8
- **Molecular weight:** Polydisperse; average molecular weight typically reported in the 4,000–6,000 Da range
- **Form:** Lyophilized powder, sealed glass vial
- **Purity:** Third-party tested; lot-matched COA available
- **Available sizes:** 100 mg, 250 mg
- **Solubility:** Freely soluble in water; gives a clear, slightly viscous solution
- **Storage (lyophilized):** 2–8 °C or below, sealed, protected from light and moisture — the powder is hygroscopic
- **Storage (reconstituted):** 2–8 °C, used within the study window
- **Chemical class:** Semi-synthetic sulfated polysaccharide (sulfated xylan), sodium salt
- **Source material:** Xylan from beechwood hemicellulose, chemically sulfated
- **Backbone:** β-1,4-linked xylopyranose units with sulfate ester substitution and occasional 4-O-methylglucuronic acid side residues
- **Also known as:** PPS, sodium pentosan polysulfate, xylan polysulfate
- **Functional description:** Glycosaminoglycan mimetic; low-affinity, heparin-like polyanion
- **Research areas:** Cartilage and connective-tissue matrix, urothelial and epithelial barrier models, glycocalyx biology, growth-factor and protease binding

## Description

Although it sits among our repair products, pentosan polysulfate sodium (PPS) is no peptide: it is a semi-synthetic sulfated polysaccharide produced by chemically sulfating xylan from beechwood hemicellulose. The result is an unbranched chain of β-1,4-linked xylopyranose units bearing sulfate esters, with a minor share of 4-O-methylglucuronic acid side groups. Chains are short for a polysaccharide — typically around 4–6 kDa — and that pairing of short length with dense negative charge gives PPS a heparin-like character without heparin's strong anticoagulant effect.

Researchers use PPS as a glycosaminoglycan mimic. Its sulfation lets it bind the same positively charged protein surfaces that native GAGs like heparan sulfate and chondroitin sulfate attach to — growth factors, complement proteins, proteases and cartilage matrix components. This has made it a frequent tool compound in cartilage and connective-tissue models, in research on epithelial barrier function and in glycocalyx studies.

## Frequently asked questions

### Does pentosan polysulfate count as a peptide?

No. Although it is listed in the tissue-repair category next to BPC-157 and TB-500, PPS is a sulfated polysaccharide — a xylan chain of β-1,4-linked xylopyranose units carrying sulfate esters. The grouping follows research area, not chemical class.

### Why isn't an exact molecular weight stated?

The material is polydisperse. Sulfating natural xylan yields a range of chain lengths and sulfation levels rather than one species, so lots are specified by their average molecular weight — usually about 4,000–6,000 Da — together with the degree of sulfation.

### Which purity documents are available?

It is tested by an independent lab, and the certificate for your lot can be requested. For a polysaccharide, the COA gives identity, average molecular weight and sulfur or sulfate content instead of the HPLC purity used for our synthetic peptides.

### How do I reconstitute and store it?

The powder absorbs moisture, so let the vial reach room temperature before opening to prevent condensation. It dissolves readily in water and aqueous buffers — add the diluent gently along the glass and swirl, don't shake. Keep sealed powder at 2–8 °C or colder, and solutions at 2–8 °C.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/pentosan-polysulfate/