# Trans-Resveratrol

> trans-Resveratrol, a stilbenoid polyphenol for sirtuin and longevity research

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/resveratrol/
- Brand: Peptide Medix EU
- Category: [Vitamins & Cofactors](https://peptidemedixeu.com/en/collections/vitamins-cofactors/)
- Purity: ≥98% trans-resveratrol by HPLC; lot-matched COA available
- CAS number: 501-36-0
- from €38 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 500 mg · 60 capsules | €38 | RESVERATROL-500-MG-60-CAPSULES |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 501-36-0
- **Molecular formula:** C14H12O3
- **Molecular weight:** 228.24 g/mol
- **Form:** Off-white to light tan powder in vegetarian capsules, sealed bottle
- **Purity:** ≥98% trans-resveratrol by HPLC; lot-matched COA available
- **Solubility:** Poorly water soluble; soluble in ethanol and DMSO for stock preparation
- **Available size:** 500 mg × 60 capsules
- **Chemical name:** 3,5,4'-trihydroxy-trans-stilbene
- **Chemical class:** Stilbenoid polyphenol (phytoalexin)
- **Isomerism:** Trans form; converts to the cis isomer on UV exposure
- **Research areas:** SIRT1 and sirtuin biology, AMPK signalling, oxidative stress, cellular senescence, xenohormesis
- **Storage:** Cool, dry place, sealed and protected from light; refrigeration extends shelf life
- **Stability note:** Sensitive to light, oxygen and alkaline pH

## Description

trans-Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a polyphenol of the stilbene class that grapevines, Japanese knotweed and other plants produce as a phytoalexin — a defensive substance made when they are attacked by fungi or stressed. Material sold commercially is mostly obtained from the roots of Polygonum cuspidatum or produced synthetically. Only the trans form really matters: the cis form has had much less study and appears readily once UV light hits the molecule — hence resveratrol products are kept away from light.

Resveratrol became a fixture in longevity research once studies claimed it activated SIRT1, an NAD-dependent deacetylase, and prolonged life in yeast and invertebrates. That view has been contested ever since: considerable evidence suggests the first assay depended on a substrate tagged with a fluorophore, and other or additional mechanisms — AMPK activation, inhibition of phosphodiesterases, direct antioxidant chemistry — have been proposed. The very controversy helps explain why resveratrol is still such a common research standard.

## Frequently asked questions

### Why the trans form in particular?

Nearly all published studies use the trans form, which predominates in nature and has been characterised far more thoroughly. UV light turns it into the cis form, which acts differently in several assays, so we specify, store and ship the material in a way that keeps it trans.

### Can I obtain a certificate of analysis?

Yes. HPLC testing is done on each lot, and the COA gives the trans-resveratrol content and confirms identity. Quote the lot number to request it and keep it with your lab records — the purity of polyphenols differs greatly between sources, and that affects whether results can be compared.

### How is it prepared for cell culture?

It barely dissolves in water, so labs usually prepare a concentrated stock in DMSO or ethanol and add it to the medium just before use. Make sure every group in the experiment — including the vehicle controls — ends up with the same final amount of solvent.

### Where does resveratrol sit compared with NMN and fisetin?

All three turn up in ageing research, but they work through different chemistry. NMN feeds NAD+ directly as a precursor; fisetin, a flavonoid, is mainly tested for senolytic activity; resveratrol, a stilbene, is investigated for its effects on sirtuin and AMPK signalling. Labs often test them side by side as a panel.

### Why do published findings vary so widely?

Outcomes depend strongly on concentration, organism, strain and formulation, and many in vitro studies use concentrations well above those reached in whole organisms, since resveratrol is quickly conjugated after absorption. Always state the model and concentration explicitly when reporting.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/resveratrol/