# Retatrutide

> Research-grade peptide agonist of the GIP, GLP-1 and glucagon receptors

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/retatrutide/
- Brand: Peptide Medix EU
- Category: [GLP-1 & Incretin Peptides](https://peptidemedixeu.com/en/collections/glp-1-peptides/)
- Purity: ≥99% by HPLC; lot-matched COA available
- CAS number: 2381089-83-2
- from €63 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 5 mg | €63 | RETATRUTIDE-5-MG |
| 10 mg | €106 | RETATRUTIDE-10-MG |
| 15 mg | €153 | RETATRUTIDE-15-MG |
| 20 mg | €204 | RETATRUTIDE-20-MG |
| 30 mg | €242 | RETATRUTIDE-30-MG |
| 48 mg | €301 | RETATRUTIDE-48-MG |
| 60 mg | €403 | RETATRUTIDE-60-MG |
| 10-vial kit · 10 x 10 mg | €922 | RETATRUTIDE-10-VIAL-KIT-10-10-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 2381089-83-2
- **Molecular formula:** C221H342N46O68
- **Molecular weight:** 4731.30 g/mol
- **Peptide class:** Acylated triple GIP/GLP-1/glucagon receptor agonist
- **Form:** Lyophilized powder, sealed glass vial with flip-off seal
- **Purity:** ≥99% by HPLC; lot-matched COA available
- **Available sizes:** 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 48 mg, 60 mg
- **Solubility:** Bacteriostatic water; dilute alkaline or phosphate buffers also used
- **Storage (lyophilized):** −20 °C, sealed and protected from light and moisture
- **Storage (reconstituted):** 2–8 °C, protected from light; use within the study window
- **Backbone length:** 39 amino acids, GIP-based sequence
- **Key modifications:** Aib residues, alpha-Me-Leu, Lys-linked (AEEA)-gamma-Glu-C20 diacid, C-terminal serinamide
- **Research areas:** Multi-receptor metabolic signaling, energy expenditure, hepatic lipid handling

## Description

Retatrutide is a lab-made peptide, 39 residues long, built on a GIP-derived backbone and designed to switch on three metabolic receptors at once: the GIP, GLP-1 and glucagon receptors. Its structure combines several stabilising tricks described by medicinal chemists — Aib (alpha-aminoisobutyric acid) residues that DPP-4 cannot cleave, an alpha-methylated leucine, and a lysine carrying an AEEA/gamma-glutamyl linker with a 20-carbon fatty diacid that lets it bind albumin reversibly — and it finishes with a serine amide at the C-terminus.

The appeal for labs is exactly this three-receptor idea. Glucagon-receptor activity layered onto incretin agonism introduces a possible effect on energy expenditure and liver fat that GLP-1 agonists — single or combined with GIP — don't provide, and separating those contributions remains an open question. Retatrutide is used to measure how potent it is at each receptor in turn, to check whether the three signals simply add up in cells and rodents, and as the reference when new multi-receptor peptides are characterised.

## Frequently asked questions

### What distinguishes retatrutide from tirzepatide?

Tirzepatide acts on two incretin receptors — GIP and GLP-1. Retatrutide adds activity at the glucagon receptor, so researchers choose it when the question concerns energy use or how the liver handles fat, not incretin signalling on its own.

### Which purity data and documents are included?

HPLC shows ≥99% purity for every lot, and mass spectrometry verifies identity. The lot's certificate is available and refers to the precise vial number delivered to you, so every assay result can be linked back to the material.

### What are the storage conditions?

Store the sealed lyophilised vial at −20 °C, away from light and humidity. After reconstitution, refrigerate at 2–8 °C in the dark and use within your documented study period, aliquoting to avoid repeated freeze–thaw cycles.

### Do you publish the complete amino-acid sequence?

Retatrutide has 39 residues, including several Aib units, an alpha-methylated leucine and a lysine-linked C20 diacid side chain. Different suppliers write modified residues in different ways, so the authoritative description of the structure is the certificate for your lot.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/retatrutide/