# Semaglutide + Vitamin B12

> Semaglutide co-formulated with methylcobalamin in one research vial

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/semaglutide-b12/
- Brand: Peptide Medix EU
- Category: [Weight Management Blends](https://peptidemedixeu.com/en/collections/weight-management-blends/)
- Purity: ≥99% by HPLC on the semaglutide input; lot-matched COA
- from €76 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 5 mg | €76 | SEMAGLUTIDE-B12-5-MG-B12 |
| 10 mg | €110 | SEMAGLUTIDE-B12-10-MG-B12 |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **Purity:** ≥99% by HPLC on the semaglutide input; lot-matched COA
- **Available sizes:** 5 mg semaglutide + B12; 10 mg semaglutide + B12
- **Storage (lyophilized):** −20 °C, sealed and protected from light and moisture
- **Storage (reconstituted):** 2–8 °C, shielded from light; use within the study window
- **Product type:** Two-component research blend, single lyophilized vial
- **Components:** Semaglutide and methylcobalamin (vitamin B12)
- **Semaglutide CAS number:** 910463-68-2
- **Semaglutide formula:** C187H291N45O59
- **Semaglutide molecular weight:** 4113.58 g/mol
- **Semaglutide class:** Acylated GLP-1 receptor agonist analog (incretin mimetic), 31-residue backbone
- **Methylcobalamin CAS number:** 13422-55-4
- **Methylcobalamin formula:** C63H91CoN13O14P
- **Methylcobalamin molecular weight:** 1344.38 g/mol
- **Appearance:** Pale pink to red lyophilized cake; pink-red solution once reconstituted
- **Research areas:** GLP-1 receptor pharmacology, appetite and glucose-handling models, one-carbon metabolism, methylation research

## Description

Here semaglutide — the fatty-acid-modified GLP-1 receptor agonist of 31 residues — shares a vial with methylcobalamin, vitamin B12 in its methylated, coenzyme form. The pairing exists because metabolic studies that use an incretin agonist often want vitamin B12 in the same preparation: when an animal eats less, it takes in fewer micronutrients, and cobalamin status is a recognised variable in one-carbon and methylation chemistry.

The pharmacology comes from semaglutide. An Aib residue at position 2 stops DPP-4 from cleaving it, and a gamma-Glu-(AEEA)₂-C18 diacid chain attached to Lys26 grips albumin tightly, giving the long half-life that made once-a-week dosing possible in the authorised medicines built on this molecule. Methylcobalamin, for its part, adds a cofactor rather than any receptor action: methionine synthase depends on it, and the cobalt held in its corrin ring colours the solution pink to red.

## Frequently asked questions

### How much of each ingredient does a vial contain?

The label states how much semaglutide the vial holds — 5 mg or 10 mg — with methylcobalamin added alongside. The exact amount of cobalamin in your lot is given on its certificate of analysis, which is the reference for both ingredients.

### What makes the solution pink or red?

That colour comes from the cobalamin: the cobalt ion inside its corrin ring absorbs visible light strongly, making B12 solutions a deep pink-red. It also tells you something — if the colour has clearly faded, the vial has been exposed to more light than it ought to have been.

### Is the blend tested by an independent lab?

Yes. Semaglutide is used only if it meets a specification of ≥99% HPLC purity, with identity confirmed by mass spectrometry, and each finished vial carries a lot number linked to that certificate. You can ask for the latest lot certificate before you buy.

### Blend or separate vials — which is better?

Choose the blend if your study keeps both ingredients at one fixed ratio — it saves you a reconstitution and a calculation. If your protocol calls for changing the ratio between semaglutide and cobalamin, or for a semaglutide-only control group, separate vials are the better choice.

### Does it need different storage from plain semaglutide?

The temperature rules are identical: −20 °C when sealed, 2–8 °C once dissolved. Light protection has to be stricter, since cobalamin breaks down under room lighting and UV far more quickly than the peptide — keep the vial in its box, wrapped up or in amber glass whenever it isn't being used.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/semaglutide-b12/