# Semaglutide

> Research-grade acylated GLP-1 receptor agonist analogue of 31 residues

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/semaglutide/
- Brand: Peptide Medix EU
- Category: [GLP-1 & Incretin Peptides](https://peptidemedixeu.com/en/collections/glp-1-peptides/)
- Purity: ≥99% by HPLC; lot-matched COA available
- CAS number: 910463-68-2
- from €38 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 2 mg | €38 | SEMAGLUTIDE-2-MG |
| 5 mg | €63 | SEMAGLUTIDE-5-MG |
| 10 mg | €93 | SEMAGLUTIDE-10-MG |
| 15 mg | €127 | SEMAGLUTIDE-15-MG |
| 20 mg | €161 | SEMAGLUTIDE-20-MG |
| 30 mg | €212 | SEMAGLUTIDE-30-MG |
| 50 mg | €301 | SEMAGLUTIDE-50-MG |
| 10-vial kit · 10 x 5 mg | €522 | SEMAGLUTIDE-10-VIAL-KIT-10-5-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 910463-68-2
- **Molecular formula:** C187H291N45O59
- **Molecular weight:** 4113.58 g/mol
- **Peptide class:** Acylated GLP-1 receptor agonist analog (incretin mimetic)
- **Form:** Lyophilized powder, sealed glass vial with flip-off seal
- **Purity:** ≥99% by HPLC; lot-matched COA available
- **Available sizes:** 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 50 mg
- **Solubility:** Bacteriostatic water; also soluble in dilute alkaline or phosphate buffers
- **Storage (lyophilized):** −20 °C, sealed and protected from light and moisture
- **Storage (reconstituted):** 2–8 °C, protected from light; use within the study window
- **Backbone length:** 31 amino acids
- **Key modifications:** Aib at position 2; Lys26 conjugated to gamma-Glu-(AEEA)2-C18 diacid
- **Research areas:** GLP-1 receptor pharmacology, incretin signaling, appetite and glucose-handling models

## Description

Semaglutide is a synthetic 31-amino-acid analogue of glucagon-like peptide-1 (GLP-1), the incretin that intestinal L-cells release after a meal. Two engineered features set it apart from the native hormone: an alpha-aminoisobutyric acid near the N-terminus that greatly reduces cleavage by dipeptidyl peptidase-4, and a gamma-glutamyl linker on a lysine carrying a C18 fatty diacid, which promotes reversible binding to albumin. In published pharmacokinetic studies these changes stretch its persistence in circulation from minutes to days.

That stability has made semaglutide one of the most cited tool compounds in incretin research. Labs use it to study GLP-1 receptor binding kinetics, cAMP accumulation and beta-arrestin recruitment in receptor-transfected cells, and downstream signalling in islet, hypothalamic and vagal-afferent preparations. It is also a standard positive control when new GLP-1, dual and triple agonists are profiled head to head.

## Frequently asked questions

### How pure is the semaglutide, and is the COA available?

At least 99% by HPLC for every lot, with mass spectrometry confirming identity. The lot's certificate is available on request and refers to the precise vial number you receive, making results traceable to your delivery.

### Which vial sizes do you offer?

5 mg, 10 mg, 20 mg, 30 mg and 50 mg lyophilised vials. Bigger vials cost less per milligram, which helps longer assay programmes; smaller ones shorten how long a reconstituted stock has to wait in the fridge.

### What is the correct storage?

Unopened lyophilised vials: −20 °C, away from light and humidity. After reconstitution: 2–8 °C, used within your documented study period. Make single-use aliquots so the stock isn't frozen and thawed over and over.

### How does semaglutide compare with tirzepatide and retatrutide?

Semaglutide activates only the GLP-1 receptor. Tirzepatide acts on both GIP and GLP-1 receptors, and retatrutide adds glucagon-receptor activity on top. Labs often test all three together to compare receptor selectivity and downstream signalling.

### Which solvent is used to reconstitute it?

Research labs typically use bacteriostatic water, or dilute alkaline or phosphate buffers when an assay needs a particular pH. Add the solvent slowly, swirl instead of shaking, and check the solution is clear before using it.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/semaglutide/