# Syn-Coll (Palmitoyl Tripeptide-5)

> Pal-KVK signal tripeptide for TGF-β and extracellular-matrix model research

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/syn-coll/
- Brand: Peptide Medix EU
- Category: [Cosmetic Signal Peptides](https://peptidemedixeu.com/en/collections/cosmetic-peptides/)
- Purity: ≥99% by HPLC; lot-matched COA available
- CAS number: 623172-56-5
- from €178 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 200 mg | €178 | SYN-COLL-200-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 623172-56-5
- **Molecular formula:** C33H65N5O5
- **Molecular weight:** 611.90 g/mol as the free peptide
- **Peptide class:** Lipidated signal tripeptide
- **Form:** Lyophilized amphiphilic peptide powder, sealed glass vial
- **Purity:** ≥99% by HPLC; lot-matched COA available
- **Solubility:** Low water solubility; validate a co-solvent or surfactant vehicle
- **Available size:** 200 mg
- **Sequence:** Palmitoyl-Lys-Val-Lys-OH (Pal-KVK)
- **Also known as:** Syn-Coll, Syn-Coll peptide, Palmitoyl Tripeptide-5
- **Research areas:** TGF-beta signaling, fibroblast matrix output, collagen-associated markers and matrix-metalloproteinase models
- **Storage:** −20 °C lyophilized, protected from light and moisture

## Description

Syn-Coll is the name under which Palmitoyl Tripeptide-5 is commonly traded: the tripeptide Lys-Val-Lys carrying a fatty acid, abbreviated Pal-KVK. A 16-carbon chain on its N-terminus makes it amphiphilic, and its two basic lysines give it a charge and formulation behaviour quite unlike other palmitoylated signal peptides — Pal-GHK or Pal-GQPR, for example.

It was developed for research on the extracellular matrix, focusing on TGF-β (transforming growth factor beta) signalling and collagen-related measures. Published work and supplier documentation have examined matrix production by fibroblasts, the activation of latent TGF-β and markers of matrix metalloproteinases — yet a large share of that evidence is commercial or specific to particular formulations, so claiming an effect for Pal-KVK requires your own analytical checks and single-ingredient controls.

Each research vial holds 200 mg of Palmitoyl Tripeptide-5 (C33H65N5O5, 611.90 g/mol), tested by HPLC and backed by a certificate for its lot. It is raw material, not a finished cosmetic, and we supply it only for laboratory work on formulations and cell models.

Comparing it with other fatty-acid-modified peptides is informative, but needs care. Matrixyl is palmitoyl pentapeptide-4, built on the sequence KTTKS; Pal-GHK carries the copper-binding GHK motif; and Pal-GQPR is a separate tetrapeptide — sharing a C16 chain does not give them a common mechanism. Pal-KVK's lysine-rich core also behaves differently in negatively charged systems, so a vehicle that works for one palmitoylated peptide has to be tested again for this one rather than assumed to work.

## Frequently asked questions

### What sequence does Syn-Coll have?

Palmitoyl-Lys-Val-Lys-OH — Pal-KVK — listed as Palmitoyl Tripeptide-5, with a molecular weight of 611.90 g/mol for the free peptide.

### Are Syn-Coll and Matrixyl the same?

No. Matrixyl usually refers to Palmitoyl Pentapeptide-4 (Pal-KTTKS), whereas Syn-Coll is Palmitoyl Tripeptide-5 (Pal-KVK). They are different compounds needing separate listings and controls.

### Is it identical to Palmitoyl Tripeptide-1?

No — Palmitoyl Tripeptide-1 is Pal-GHK, and this product is Pal-KVK. They use the same lipidation approach but differ in sequence and research rationale.

### Why might a co-solvent be needed?

The 16-carbon palmitoyl chain makes it hard to dissolve in water on its own and encourages it to stick to surfaces or clump together. Adding a co-solvent or surfactant — and recording which — can make results more reproducible, provided your controls contain the same vehicle.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/syn-coll/