# Tesofensine

> Research capsules (0.5 mg) of a triple monoamine reuptake inhibitor

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/tesofensine/
- Brand: Peptide Medix EU
- Category: [Fat-Loss & Metabolic Peptides](https://peptidemedixeu.com/en/collections/fat-loss-peptides/)
- Purity: Analytically tested; certificate of analysis available
- CAS number: 402856-42-2
- from €72 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 0.5 mg · 30 capsules | €72 | TESOFENSINE-0-5-MG-30-CAPSULES |
| 0.5 mg · 60 capsules | €127 | TESOFENSINE-0-5-MG-60-CAPSULES |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 402856-42-2
- **Form:** Oral-format capsules, 0.5 mg per capsule, in a sealed bottle
- **Purity:** Analytically tested; certificate of analysis available
- **Available sizes:** 30 capsules, 60 capsules
- **Compound class:** Small-molecule triple monoamine reuptake inhibitor (non-peptide)
- **Molecular targets:** Norepinephrine, dopamine and serotonin transporters (NET, DAT, SERT)
- **Research areas:** Monoamine transporter pharmacology, feeding behavior, reward and motivation circuits
- **Storage:** Room temperature, sealed, dry and protected from light
- **Handling note:** Centrally active compound; handle with standard controlled-laboratory precautions

## Description

Although catalogues often place it among peptides, tesofensine is in fact a synthetic small molecule. It blocks the presynaptic reuptake transporters for three monoamines — noradrenaline, dopamine and serotonin. Originally it was pursued for neurodegenerative conditions, where clinical studies missed their goals; appetite and body-weight changes noticed in those trials are what later turned it into a research subject.

Its value as a lab tool lies in hitting all three transporters at once rather than just one. It is used in binding and uptake-inhibition assays that rank affinity across NET, DAT and SERT, in microdialysis experiments tracking extracellular monoamine levels in defined brain regions, and in rodent feeding studies where selective antagonists reveal which neurotransmitter system accounts for reduced intake.

## Frequently asked questions

### Does tesofensine count as a peptide?

No — it is a small-molecule inhibitor of three monoamine reuptake transporters. Shared interest in food-intake research is why it often appears beside metabolic peptides, but chemically and mechanistically it has nothing in common with them.

### On which transporters does it act?

NET, DAT and SERT — the transporters for noradrenaline, dopamine and serotonin. How its affinity is spread over those three sets it apart from selective reuptake inhibitors and underlies the behaviour seen in animal work.

### In what form do I receive it?

Capsules of 0.5 mg in sealed bottles containing 30 or 60. Unlike most of our range, which is lyophilised powder in vials, nothing has to be reconstituted.

### Which documents can I request?

The certificate of analysis for your lot, giving identity and purity. Filing it with your lab notes keeps a clear link between the analytical results and the material you used.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/tesofensine/