# Tripeptide-29 (Gly-Pro-Hyp)

> Collagen tripeptide Gly-Pro-Hyp for matrix, stability and enzyme studies

All products are sold strictly for laboratory research use only. Not for human or veterinary use.

- Web page: https://peptidemedixeu.com/en/products/tripeptide-29/
- Brand: Peptide Medix EU
- Category: [Cosmetic Signal Peptides](https://peptidemedixeu.com/en/collections/cosmetic-peptides/)
- Purity: ≥99% by HPLC; lot-matched COA available
- CAS number: 2239-67-0
- from €178 (EUR)

## Sizes and prices (EUR)

| Size | Price | SKU |
| --- | --- | --- |
| 200 mg | €178 | TRIPEPTIDE-29-200-MG |

_Catalog prices at build time; the web page and checkout are authoritative._

## Specifications

- **CAS number:** 2239-67-0
- **Molecular formula:** C12H19N3O5
- **Molecular weight:** 285.30 g/mol
- **Amino acid sequence:** Gly-Pro-Hyp (glycyl-prolyl-hydroxyproline)
- **Chain length:** 3 residues
- **Peptide class:** Collagen-derived imino-acid-rich tripeptide
- **Form:** Lyophilized powder, sealed glass vial
- **Purity:** ≥99% by HPLC; lot-matched COA available
- **Solubility:** Water-soluble
- **Available size:** 200 mg
- **Also known as:** Gly-Pro-Hyp, GPH, collagen tripeptide, Tripeptide-29
- **Research areas:** Collagen hydrolysate composition, peptide transport, fibroblast models, glycation, oxidative stress and DPP-IV assays
- **Storage:** −20 °C lyophilized; keep sealed and dry

## Description

Tripeptide-29 is glycyl-L-prolyl-L-hydroxyproline (Gly-Pro-Hyp) — a motif repeated throughout collagen and frequently found among the small peptides released when collagen is hydrolysed. The hydroxyproline is what distinguishes it from Gly-Pro-Pro, supplying the hydroxyl group that is central to many studies of collagen structure and peptide transport.

Its uses range from collagen-model stability and the uptake and metabolism of collagen-derived peptides to fibroblast responses to hydrolysate fractions, glycation and oxidative-stress assays, and in-vitro enzyme studies involving DPP-IV. Having one purified tripeptide lets researchers test whether an effect attributed to a complex collagen hydrolysate can really be reproduced by Gly-Pro-Hyp on its own.

It comes as a 200 mg lyophilised vial (CAS 2239-67-0, C12H19N3O5, 285.30 g/mol), HPLC-tested with lot documentation, and is meant solely for analytical, biochemical and cell-model research — not as a food, supplement, cosmetic or medicine.

Precise identity matters with this reagent. Gly-Pro-Hyp is often discussed alongside Pro-Hyp and Hyp-Gly — different molecules from the same hydrolysate literature — and hydroxyproline has its own stereocentre, so catalogue entries should specify 4-hydroxy-L-proline rather than just “Hyp”. Supplying the tripeptide as a single purified compound with documented HPLC purity is what lets it act as an analytical reference for quantifying mixed hydrolysate fractions.

## Frequently asked questions

### What is Tripeptide-29?

The defined collagen tripeptide Gly-Pro-Hyp (glycyl-prolyl-hydroxyproline), one of the motifs and breakdown products that recur in collagen.

### Is it the same thing as collagen hydrolysate?

No. A hydrolysate contains a multitude of peptides of varying length and sequence, whereas this vial holds one purified tripeptide — ideal as an analytical standard or single-agent control.

### Why does hydroxyproline matter?

It is a hallmark of collagen and influences peptide shape, susceptibility to enzymes and how the peptide is detected. Note, though, that measuring total hydroxyproline cannot prove intact Gly-Pro-Hyp is present.

### Which purity documents are provided?

It is released at ≥99% by HPLC with a certificate for the lot. For quantitative protocols, take into account any counter-ion or water content listed in the lot documentation.

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All products offered on this website are intended solely for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics or dietary supplements, and are not intended to diagnose, treat, cure or prevent any disease. Products must not be introduced into humans or animals in any manner. By purchasing, you confirm that you are a qualified researcher and accept full responsibility for handling and storage in accordance with applicable laws.

Peptide Medix EU · https://peptidemedixeu.com/en/products/tripeptide-29/