- HPLC purity ≥99%, with a COA for each lot on request
- Certificate of analysis tied to your lot number
- Tracked EU delivery, dispatched the next working day
Ecnoglutide
Research-grade long-acting GLP-1 receptor agonist with cAMP-biased signalling (XW003)
In stock2 formats available
€97Range €97 – €170
This listing is currently unavailable. Contact us and we will tell you when it is back or suggest an equivalent.
Ask about this listing or request its COA- FormLyophilized powder in a sealed glass vial with flip-off cap
- Research areasBiased GLP-1R agonism, receptor internalisation and desensitisation, glucose handling and appetite models
For laboratory research use only. Sold exclusively for in-vitro laboratory research by qualified professionals. Not for human or veterinary use, and not a medicine, food, cosmetic or dietary supplement. Terms and Conditions
Overview
Key facts
Ecnoglutide — XW003 in development papers — is a long-acting analogue that activates the glucagon-like peptide-1 receptor.
- Purity
- ≥99% by HPLC; lot-matched COA available
- Form
- Lyophilized powder in a sealed glass vial with flip-off cap
- Storage
- −20 °C, sealed and protected from light and moisture
- Available sizes
- 5 mg · 10 mg
For research use only. Not for human consumption.
Ecnoglutide — XW003 in development papers — is a long-acting analogue that activates the glucagon-like peptide-1 receptor. As with others in its class, it is built on the GLP-1 sequence with changes that protect it from dipeptidyl peptidase-4 and a fatty side chain that encourages albumin binding, which together keep it in circulation far longer than native GLP-1. What sets it apart in the published descriptions is how it signals: it is characterised as cAMP-biased, favouring Gs-coupled cAMP production over beta-arrestin recruitment at the receptor.
Ecnoglutide is supplied as lyophilised powder in sealed 5 mg and 10 mg vials, HPLC-purified to ≥99% and released with a certificate of analysis for the lot. It is dispatched from our EU warehouse and sold exclusively for laboratory research.
Specifications
Supply & purity
- Form
- Lyophilized powder in a sealed glass vial with flip-off cap
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 5 mg, 10 mg
- Solubility
- Bacteriostatic water; also soluble in dilute alkaline or phosphate buffers
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, protected from light; use within the study window
Additional detail
- Research code
- XW003
- Compound class
- Acylated long-acting GLP-1 receptor agonist analogue (incretin mimetic)
- Receptor target
- Glucagon-like peptide-1 receptor (GLP-1R), a class B GPCR
- Signalling profile
- Reported as cAMP-biased, with reduced beta-arrestin recruitment relative to balanced agonists
- Design features
- DPP-4-resistant backbone modification plus a fatty-acid side chain for albumin association
- Research areas
- Biased GLP-1R agonism, receptor internalisation and desensitisation, glucose handling and appetite models
- Regulatory status
- Investigational; not approved by the FDA for any indication
Questions about Ecnoglutide
What is ecnoglutide?
A long-acting GLP-1 receptor agonist analogue with the research code XW003. It carries the class's typical backbone changes and fatty-acid acylation, and published work describes it as preferring cAMP signalling at the receptor.
How does it compare with semaglutide?
Both are acylated single agonists at GLP-1R, yet ecnoglutide is reported to favour Gs/cAMP signalling while recruiting less beta-arrestin. Comparative assays exploit this to separate the effects of signalling bias from those of receptor coverage.
What purity and documents come with it?
Every lot is HPLC-purified to ≥99% and released with its own certificate of analysis for purity and identity. Tell us the lot number on your vial and we will send the matching COA.
How is reconstituted ecnoglutide stored?
At 2–8 °C, protected from light, for no longer than your protocol allows. Divide it into aliquots before freezing at −20 °C to spare it the freeze–thaw cycles that damage acylated peptides most quickly.
Can I purchase ecnoglutide for personal use?
No. It is a research chemical, sold only for use in the laboratory.
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