- HPLC purity ≥99%, with a COA for each lot on request
- Certificate of analysis tied to your lot number
- Tracked EU delivery, dispatched the next working day
Retatrutide
Research-grade peptide agonist of the GIP, GLP-1 and glucagon receptors
In stock8 formats availableCAS 2381089-83-2
€63Range €63 – €922
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Ask about this listing or request its COA- FormLyophilized powder, sealed glass vial with flip-off seal
- Mol. weight4731.30 g/mol
- Research areasMulti-receptor metabolic signaling, energy expenditure, hepatic lipid handling
For laboratory research use only. Sold exclusively for in-vitro laboratory research by qualified professionals. Not for human or veterinary use, and not a medicine, food, cosmetic or dietary supplement. Terms and Conditions
Overview
Key facts
Retatrutide is a lab-made peptide, 39 residues long, built on a GIP-derived backbone and designed to switch on three metabolic receptors at once: the GIP, GLP-1 and glucagon receptors.
- CAS number
- 2381089-83-2
- Molecular formula
- C221H342N46O68
- Molecular weight
- 4731.30 g/mol
- Purity
- ≥99% by HPLC; lot-matched COA available
- Form
- Lyophilized powder, sealed glass vial with flip-off seal
- Storage
- −20 °C, sealed and protected from light and moisture
- Available sizes
- 5 mg · 10 mg · 15 mg · 20 mg · 30 mg · 48 mg · 60 mg · 10-vial kit · 10 x 10 mg
For research use only. Not for human consumption.
Retatrutide is a lab-made peptide, 39 residues long, built on a GIP-derived backbone and designed to switch on three metabolic receptors at once: the GIP, GLP-1 and glucagon receptors. Its structure combines several stabilising tricks described by medicinal chemists — Aib (alpha-aminoisobutyric acid) residues that DPP-4 cannot cleave, an alpha-methylated leucine, and a lysine carrying an AEEA/gamma-glutamyl linker with a 20-carbon fatty diacid that lets it bind albumin reversibly — and it finishes with a serine amide at the C-terminus.
The appeal for labs is exactly this three-receptor idea. Glucagon-receptor activity layered onto incretin agonism introduces a possible effect on energy expenditure and liver fat that GLP-1 agonists — single or combined with GIP — don't provide, and separating those contributions remains an open question. Retatrutide is used to measure how potent it is at each receptor in turn, to check whether the three signals simply add up in cells and rodents, and as the reference when new multi-receptor peptides are characterised.
What sets this listing apart
Retatrutide – vial, 5/10/15/20/30/48/60 mg. Lyophilized powder, sealed glass vial with flip-off seal. Other Retatrutide listings differ in format, fill or combination partners; the specification and COA always refer to the listing you order.
Same compound, other listings
Specifications
Identity
- CAS number
- 2381089-83-2
- Molecular formula
- C221H342N46O68
- Molecular weight
- 4731.30 g/mol
- Peptide class
- Acylated triple GIP/GLP-1/glucagon receptor agonist
Supply & purity
- Form
- Lyophilized powder, sealed glass vial with flip-off seal
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 48 mg, 60 mg
- Solubility
- Bacteriostatic water; dilute alkaline or phosphate buffers also used
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, protected from light; use within the study window
Additional detail
- Backbone length
- 39 amino acids, GIP-based sequence
- Key modifications
- Aib residues, alpha-Me-Leu, Lys-linked (AEEA)-gamma-Glu-C20 diacid, C-terminal serinamide
- Research areas
- Multi-receptor metabolic signaling, energy expenditure, hepatic lipid handling
Questions about Retatrutide
What distinguishes retatrutide from tirzepatide?
Tirzepatide acts on two incretin receptors — GIP and GLP-1. Retatrutide adds activity at the glucagon receptor, so researchers choose it when the question concerns energy use or how the liver handles fat, not incretin signalling on its own.
Which purity data and documents are included?
HPLC shows ≥99% purity for every lot, and mass spectrometry verifies identity. The lot's certificate is available and refers to the precise vial number delivered to you, so every assay result can be linked back to the material.
What are the storage conditions?
Store the sealed lyophilised vial at −20 °C, away from light and humidity. After reconstitution, refrigerate at 2–8 °C in the dark and use within your documented study period, aliquoting to avoid repeated freeze–thaw cycles.
Do you publish the complete amino-acid sequence?
Retatrutide has 39 residues, including several Aib units, an alpha-methylated leucine and a lysine-linked C20 diacid side chain. Different suppliers write modified residues in different ways, so the authoritative description of the structure is the certificate for your lot.
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