- HPLC purity ≥99%, documented per lot
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Melanotan II (MT-2)
Cyclic α-MSH analogue acting broadly across melanocortin receptors
In stock2 formats availableCAS 121062-08-6
€55Range €55 – €97
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Ask about this listing or request its COA- FormLyophilized white to off-white powder, sealed glass vial
- Mol. weight1024.18 g/mol
- Research areasMelanogenesis and pigmentation, appetite and energy balance, melanocortin receptor selectivity
For laboratory research use only. Sold exclusively for in-vitro laboratory research by qualified professionals. Not for human or veterinary use, and not a medicine, food, cosmetic or dietary supplement. Terms and Conditions
Overview
Key facts
Melanotan II (MT-2) is a synthetic cyclic lactam analogue of α-melanocyte-stimulating hormone that originated in university research on melanocortin structure–activity relationships.
- CAS number
- 121062-08-6
- Molecular formula
- C50H69N15O9
- Molecular weight
- 1024.18 g/mol
- Amino acid sequence
- Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
- Purity
- ≥99% by HPLC; lot-matched COA
- Form
- Lyophilized white to off-white powder, sealed glass vial
- Storage
- −20 °C, protected from light and moisture
- Available sizes
- 10 mg · 20 mg
For research use only. Not for human consumption.
Melanotan II (MT-2) is a synthetic cyclic lactam analogue of α-melanocyte-stimulating hormone that originated in university research on melanocortin structure–activity relationships. A ring formed between aspartate and lysine side chains fixes the pharmacophore in its active shape, while N-terminal acetylation, a norleucine and a D-phenylalanine slow down proteolysis. The outcome is a small heptapeptide far more stable and potent than native α-MSH.
In contrast to its metabolite PT-141, Melanotan II keeps its C-terminal amide and acts as a broad, fairly unselective agonist at MC1R, MC3R, MC4R and MC5R. That wide reach made it a staple research tool: via MC1R it links to melanogenesis and pigmentation, while via MC3R and MC4R it links to central studies of feeding, energy expenditure and arousal. Very few single compounds open up so many receptor subtypes at once.
Specifications
Identity
- CAS number
- 121062-08-6
- Molecular formula
- C50H69N15O9
- Molecular weight
- 1024.18 g/mol
- Amino acid sequence
- Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
- Peptide class
- Cyclic heptapeptide; α-MSH (melanocortin) analogue
Supply & purity
- Form
- Lyophilized white to off-white powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA
- Available sizes
- 10 mg, 20 mg
- Solubility
- Soluble in bacteriostatic or sterile water; also soluble in dilute acetic acid
Handling & storage
- Storage (lyophilized)
- −20 °C, protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, protected from light; aliquot to limit freeze–thaw
Additional detail
- Receptor targets
- Non-selective agonist at MC1R, MC3R, MC4R and MC5R
- Research areas
- Melanogenesis and pigmentation, appetite and energy balance, melanocortin receptor selectivity
Questions about Melanotan II (MT-2)
In what way do Melanotan I and II differ?
Melanotan I (afamelanotide) is a linear α-MSH analogue selective for MC1R; Melanotan II is cyclic and unselective, acting at MC1R, MC3R, MC4R and MC5R. MT-1 is chosen to study pigmentation pathways alone, MT-2 when broad melanocortin activity is what the experiment needs.
Is a certificate of analysis available for your MT-2?
Yes. Reverse-phase HPLC (≥99% purity) and mass spectrometry (identity) characterise each lot, and the lot's certificate can be requested. The batch number on your vial matches the document, keeping results traceable.
Which sizes are sold?
Lyophilised vials of 10 mg and 20 mg. The 10 mg vial fits short assay series or method development; with 20 mg, a longer study can run on one lot from start to finish, eliminating batch differences as a confounder.
How do I reconstitute and store Melanotan II?
It dissolves readily in bacteriostatic or sterile water — add the solvent slowly along the glass and swirl, don't shake. Keep sealed vials at −20 °C away from light and moisture; store the solution at 2–8 °C in aliquots to avoid repeated freezing and thawing.
What is the reason for studying it together with PT-141?
PT-141 is the free-acid metabolite of Melanotan II, lacking the C-terminal amide. Testing both reveals what that amide contributes: MT-2 retains strong MC1R activity, whereas PT-141 largely loses it — an ideal matched pair for receptor-selectivity work.
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