- HPLC purity ≥98%, with a COA for each lot on request
- Certificate of analysis tied to your lot number
- Tracked EU delivery, dispatched the next working day
Metabolic & Circadian Compounds
Cardarine (GW-501516)
PPARδ agonist research chemical (non-peptide) as capsules or 20 mg/mL solution
In stock2 formats availableCAS 317318-70-0
€55Range €55 – €68
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Ask about this listing or request its COA- FormOral capsules in a sealed bottle, or 30 mL solution in an amber dropper bottle
- Mol. weight453.50 g/mol
- Research areasFatty-acid oxidation and PDK4/CPT1 expression, muscle fibre-type gene programmes, lipid and lipoprotein handling, anti-doping detection chemistry
For laboratory research use only. Sold exclusively for in-vitro laboratory research by qualified professionals. Not for human or veterinary use, and not a medicine, food, cosmetic or dietary supplement. Terms and Conditions
Overview
Key facts
GW-501516 — often sold as Cardarine and also labelled GW1516 or endurobol — is a synthetic small molecule that binds peroxisome proliferator-activated receptor delta (PPARδ, also PPARβ/δ) with high affinity as an agonist.
- CAS number
- 317318-70-0
- Molecular formula
- C21H18F3NO3S2
- Molecular weight
- 453.50 g/mol
- Purity
- ≥98% by HPLC; lot-matched COA available
- Form
- Oral capsules in a sealed bottle, or 30 mL solution in an amber dropper bottle
- Storage
- Room temperature in the sealed container, dry and protected from light; refrigerate stock solutions
- Available sizes
- 10 mg · 60 capsules · 30 mL liquid · 20 mg/mL
For research use only. Not for human consumption.
GW-501516 — often sold as Cardarine and also labelled GW1516 or endurobol — is a synthetic small molecule that binds peroxisome proliferator-activated receptor delta (PPARδ, also PPARβ/δ) with high affinity as an agonist. It is neither a peptide nor a SARM: chemically it is a phenoxyacetic acid containing a thiazole ring and a trifluoromethylphenyl group, with a molecular weight of about 453.5 g/mol.
PPARdelta is a transcription factor switched on by ligand binding; it pairs with the retinoid X receptor and attaches to peroxisome proliferator response elements in gene promoters, so studies in this field mostly read out gene expression. Researchers measure PDK4 and CPT1 transcripts, rates of fatty-acid oxidation, muscle fibre-type gene programmes and the handling of lipids and lipoproteins, both in cultured myotubes and in rodents. A completely separate literature is analytical: validated LC-MS/MS assays for the parent molecule and its sulfoxide and sulfone metabolites, built for anti-doping control, where it is classed as a metabolic modulator. Both of our formats use the same material, HPLC-tested to ≥98%: sixty 10 mg capsules, or 30 mL of a 20 mg/mL solution for volumetric work.
Specifications
Identity
- CAS number
- 317318-70-0
- Molecular formula
- C21H18F3NO3S2
- Molecular weight
- 453.50 g/mol
Supply & purity
- Form
- Oral capsules in a sealed bottle, or 30 mL solution in an amber dropper bottle
- Purity
- ≥98% by HPLC; lot-matched COA available
- Available sizes
- 10 mg × 60 capsules; 30 mL liquid at 20 mg/mL
- Solubility
- Poorly water soluble; typically dissolved in DMSO or ethanol for in-vitro work
Additional detail
- Compound class
- Non-steroidal PPARδ (PPARβ/δ) agonist; nuclear receptor ligand
- Also known as
- Cardarine, GW1516, GSK-516, endurobol
- Chemical description
- Phenoxyacetic acid linked through a thioether to a 4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole
- Molecular target
- PPARδ; acts with RXR as a heterodimeric transcription factor
- Research areas
- Fatty-acid oxidation and PDK4/CPT1 expression, muscle fibre-type gene programmes, lipid and lipoprotein handling, anti-doping detection chemistry
- Regulatory status
- Not an approved drug; not a dietary supplement or dietary ingredient; WADA prohibited (S4 metabolic modulators)
- Storage
- Room temperature in the sealed container, dry and protected from light; refrigerate stock solutions
Questions about Cardarine (GW-501516)
Does Cardarine belong to the SARMs?
No. Although it is often sold next to them, GW-501516 has no action at the androgen receptor. It is a PPARδ agonist, a nuclear-receptor ligand that changes transcription of metabolic genes. Putting it with SARMs is a sales habit, not a pharmacological classification.
Which purity data and documents are provided?
Every lot is HPLC-analysed to ≥98% purity with identity confirmation, and you can request the lot's certificate of analysis. Independent tests of consumer products in this category have frequently revealed mislabelled content — precisely why documentation at lot level matters.
How is it prepared for cell-based experiments?
GW-501516 dissolves poorly in water. Cell studies usually make a concentrated DMSO or ethanol stock and dilute it into medium, keeping the final vehicle level low and identical in control wells. Stocks are normally kept cold and shielded from light.
Can doping tests detect it?
Yes. WADA lists it as a prohibited metabolic modulator, and validated LC-MS/MS methods pick up the parent compound as well as its sulfoxide and sulfone metabolites. A large share of the analytical literature on the molecule was produced for exactly that purpose.
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