- HPLC purity ≥99%, with a COA for each lot on request
- Certificate of analysis tied to your lot number
- Tracked EU delivery, dispatched the next working day
CJC-1295 with DAC
GHRH analogue with a drug affinity complex (DAC) that binds albumin
In stock3 formats availableCAS 863288-34-0
€46Range €46 – €153
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Ask about this listing or request its COA- FormLyophilized powder, sealed glass vial
- Mol. weight3647.28 g/mol
- Research areasSustained secretagogue signalling, receptor desensitisation, IGF-1 dynamics
For laboratory research use only. Sold exclusively for in-vitro laboratory research by qualified professionals. Not for human or veterinary use, and not a medicine, food, cosmetic or dietary supplement. Terms and Conditions
Overview
Key facts
CJC-1295 with DAC is a synthetic analogue of growth hormone-releasing hormone.
- CAS number
- 863288-34-0
- Molecular formula
- C165H269N47O46
- Molecular weight
- 3647.28 g/mol
- Purity
- ≥99% by HPLC; lot-matched COA available
- Form
- Lyophilized powder, sealed glass vial
- Storage
- −20 °C, sealed and protected from light and moisture
- Available sizes
- 2 mg · 5 mg · 10 mg
For research use only. Not for human consumption.
CJC-1295 with DAC is a synthetic analogue of growth hormone-releasing hormone. It uses the Modified GRF 1-29 sequence as its backbone and adds a lysine at position 30 bearing a maleimidopropionyl group — the drug affinity complex (DAC). This maleimide couples to the free thiol of cysteine-34 on circulating serum albumin, creating a covalent conjugate that protects the peptide from renal elimination and peptidases.
That chemistry is the molecule's reason for being. Unconjugated GHRH fragments are cleared within minutes, whereas the albumin-linked form has been reported to last for days in animal models, giving continuous instead of pulsed receptor exposure. Researchers therefore deploy it as a long-acting comparator to separate out the effects of sustained GHRH receptor occupancy on somatotroph signalling, receptor desensitisation and downstream IGF-1.
What sets this listing apart
CJC-1295 with DAC – vial, 2/5/10 mg. Lyophilized powder, sealed glass vial. Other CJC-1295 with DAC listings differ in format, fill or combination partners; the specification and COA always refer to the listing you order.
Same compound, other listings
Specifications
Identity
- CAS number
- 863288-34-0
- Molecular formula
- C165H269N47O46
- Molecular weight
- 3647.28 g/mol
- Peptide class
- Long-acting GHRH analogue (GHRH-R agonist)
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 2 mg, 5 mg, 10 mg
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, used within the study window
Additional detail
- Also known as
- CJC-1295 DAC, DAC:GRF, drug affinity complex GHRH analogue
- Structure
- Modified GRF 1-29 (D-Ala2, Gln8, Ala15, Leu27) extended with Lys30-maleimidopropionamide
- Conjugation chemistry
- Maleimide–thiol addition to cysteine-34 of serum albumin
- Research areas
- Sustained secretagogue signalling, receptor desensitisation, IGF-1 dynamics
Questions about CJC-1295 with DAC
What does “DAC” stand for?
Drug affinity complex: the maleimidopropionyl group on the C-terminal lysine, which reacts with cysteine-34 of serum albumin. The covalent bond formed shields the peptide from clearance and greatly prolongs how long it remains in circulation in animal models.
Which buffers must I avoid when reconstituting?
Do not use solvents that contain free thiols or reducing agents — DTT, TCEP, beta-mercaptoethanol and the like. They react with the maleimide and wipe out the albumin-binding function. Bacteriostatic or sterile water is the normal lab choice.
Can I get a Certificate of Analysis?
Yes. An independent laboratory tests every lot by HPLC for identity and ≥99% purity, and the certificate for your lot can be requested. Check that the lot number on the vial corresponds to the certificate before logging the material in your inventory.
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