- Purity ≥95% by SDS-PAGE and HPLC; per-lot COA on request
- Certificate of analysis tied to your lot number
- Tracked EU delivery, dispatched the next working day
ACE-031
Soluble ActRIIB-Fc fusion used in research as a myostatin-capturing decoy
In stock1 format available
€191
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Ask about this listing or request its COA- FormLyophilized recombinant protein, sealed glass vial
- Research areasMyostatin-pathway inhibition, muscle-mass regulation, muscular dystrophy models, bone density models
For laboratory research use only. Sold exclusively for in-vitro laboratory research by qualified professionals. Not for human or veterinary use, and not a medicine, food, cosmetic or dietary supplement. Terms and Conditions
Overview
Key facts
ACE-031 is a recombinant fusion protein: the extracellular, ligand-binding part of human activin receptor type IIB (ActRIIB) fused to the Fc region of human IgG1.
- Purity
- ≥95% by SDS-PAGE and HPLC; lot-matched COA available
- Form
- Lyophilized recombinant protein, sealed glass vial
- Storage
- −20 °C, protected from light and moisture
- Available size
- 1 mg
For research use only. Not for human consumption.
ACE-031 is a recombinant fusion protein: the extracellular, ligand-binding part of human activin receptor type IIB (ActRIIB) fused to the Fc region of human IgG1. Instead of occupying a receptor on the cell membrane, it acts as a decoy in solution — myostatin, activin A and other TGF-β superfamily ligands attach to the soluble receptor domain and are thereby withdrawn from the pool that could signal via membrane ActRIIB. The Fc segment makes the molecule a dimer and gives it a far longer circulating half-life than the bare receptor fragment.
How broadly it captures ligands is what defines its experimental value. Besides myostatin, the soluble ActRIIB domain binds activin A, GDF-11 and a number of bone morphogenetic proteins, so a phenotype cannot be credited to myostatin blockade unless more selective reagents are run in parallel — the reason we stock the myostatin propeptide and follistatin-344 alongside it. Being a recombinant protein rather than a synthetic peptide, it is released against a 95% SDS-PAGE and HPLC specification instead of the 99% HPLC limit used for short sequences, and it needs protein-style handling: the disulfide-bonded Fc homodimer aggregates if shaken hard or frozen and thawed repeatedly, so reconstitute gently, add carrier protein to dilute stocks and aliquot the single 1 mg vial before freezing.
Specifications
Supply & purity
- Form
- Lyophilized recombinant protein, sealed glass vial
- Purity
- ≥95% by SDS-PAGE and HPLC; lot-matched COA available
- Available sizes
- 1 mg
- Solubility
- Sterile or bacteriostatic water; carrier protein often added for dilute stocks
Handling & storage
- Storage (lyophilized)
- −20 °C, protected from light and moisture
- Storage (reconstituted)
- 2–8 °C for immediate work; aliquot and freeze for longer studies
Additional detail
- Protein class
- Fc-fusion protein; soluble activin receptor type IIB decoy
- Construct
- Extracellular domain of human ActRIIB fused to human IgG1 Fc
- Quaternary structure
- Disulfide-linked homodimer, as with other IgG1 Fc fusions
- Principal binding partners
- Myostatin (GDF-8), activin A, GDF-11 and selected BMPs
- Also known as
- ActRIIB-Fc, soluble activin receptor type IIB fusion protein, ramatercept
- Research areas
- Myostatin-pathway inhibition, muscle-mass regulation, muscular dystrophy models, bone density models
Questions about ACE-031
What is ACE-031, precisely?
A recombinant fusion of the ligand-binding extracellular domain of human activin receptor type IIB with the Fc portion of human IgG1. The receptor domain traps myostatin and related ligands, while the Fc part forms the dimer and prolongs the molecule's lifetime in circulation.
How does it compare with Follistatin-344?
Both neutralise ligands of the same pathway, but by different routes. Follistatin is a native binding protein that envelops activin and myostatin, whereas ACE-031 is an engineered, soluble version of the receptor. Many study designs include both as side-by-side arms.
Is ACE-031 tested by an independent lab?
Yes. An independent laboratory analyses every lot, measuring purity by SDS-PAGE and HPLC and confirming identity with suitable protein techniques. The certificate of analysis carries your vial's lot number and is available on request.
What storage does ACE-031 need?
Store unopened lyophilised vials at −20 °C away from light and moisture. Once reconstituted, keep at 2–8 °C for work that follows immediately, or aliquot and freeze for longer projects. Fc-fusion proteins aggregate with repeated freeze–thaw and rough mixing, so avoid both.
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