- HPLC purity ≥99%, with a COA for each lot on request
- Certificate of analysis tied to your lot number
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Hexarelin
GHS-R1a hexapeptide agonist with a 2-methyl-Trp and CD36 binding activity
In stock2 formats availableCAS 140703-51-1
€38Range €38 – €63
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Ask about this listing or request its COA- FormLyophilized powder, sealed glass vial
- Mol. weight887.04 g/mol
- Research areasSecretagogue pharmacology, cardiac signalling, receptor desensitisation
For laboratory research use only. Sold exclusively for in-vitro laboratory research by qualified professionals. Not for human or veterinary use, and not a medicine, food, cosmetic or dietary supplement. Terms and Conditions
Overview
Key facts
Hexarelin is a synthetic six-residue growth hormone secretagogue derived from GHRP-6 by adding one methyl group: position 2 carries 2-methyl-D-tryptophan in place of D-tryptophan.
- CAS number
- 140703-51-1
- Molecular formula
- C47H58N12O6
- Molecular weight
- 887.04 g/mol
- Amino acid sequence
- His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2
- Purity
- ≥99% by HPLC; lot-matched COA available
- Form
- Lyophilized powder, sealed glass vial
- Storage
- −20 °C, sealed and protected from light and moisture
- Available sizes
- 2 mg · 5 mg
For research use only. Not for human consumption.
Hexarelin is a synthetic six-residue growth hormone secretagogue derived from GHRP-6 by adding one methyl group: position 2 carries 2-methyl-D-tryptophan in place of D-tryptophan. This tiny change reportedly boosts metabolic stability and potency at the secretagogue receptor GHS-R1a and gives the sequence His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2.
Hexarelin stands out from the other GHRPs in the literature because of a second target. Cardiovascular research found that it binds CD36, a scavenger receptor present in heart tissue, and a number of studies have explored cardiac effects of hexarelin in models where growth hormone release does not explain what is seen. It therefore serves both as a reference secretagogue and as a probe for signalling independent of GHS-R1a.
Specifications
Identity
- CAS number
- 140703-51-1
- Molecular formula
- C47H58N12O6
- Molecular weight
- 887.04 g/mol
- Amino acid sequence
- His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2
- Chain length
- 6 residues, C-terminal amide
- Peptide class
- Growth hormone releasing peptide (GHRP), GHS-R1a agonist
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 2 mg, 5 mg
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
Additional detail
- Also known as
- Examorelin, EP-23905
- Secondary target
- CD36 scavenger receptor, studied in cardiac tissue models
- Research areas
- Secretagogue pharmacology, cardiac signalling, receptor desensitisation
Questions about Hexarelin
What is hexarelin?
A synthetic hexapeptide that activates GHS-R1a, the growth hormone secretagogue receptor — structurally, GHRP-6 with an added methyl group. Labs use it as a potent reference secretagogue and to probe CD36-dependent signalling in the heart.
How is it different from GHRP-6?
Structurally, only by a methyl group on the D-tryptophan in position 2. That one alteration has been reported to raise metabolic stability and potency at GHS-R1a, which is why the two are frequently compared in structure–activity studies.
What is the link to CD36?
Besides GHS-R1a, hexarelin binds the cardiac scavenger receptor CD36. Binding assays and isolated-heart experiments have exploited this to study cardiac effects that remain in models where growth hormone release cannot explain the findings.
Is purity verified independently?
Yes. An independent lab HPLC-tests each lot for identity and ≥99% purity, and the certificate can be requested. Confirm that the lot number on your vial matches the certificate you receive.
Which sizes are available?
Lyophilised vials of 2 mg and 5 mg. The 2 mg size is suited to receptor binding assays and pilots; 5 mg is better value for longer comparisons across the secretagogue family.
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