- Analytical testing on each lot; COA on request
- Certificate of analysis tied to your lot number
- Tracked EU delivery, dispatched the next working day
Tesofensine
Research capsules (0.5 mg) of a triple monoamine reuptake inhibitor
In stock2 formats availableCAS 402856-42-2
€72Range €72 – €127
This listing is currently unavailable. Contact us and we will tell you when it is back or suggest an equivalent.
Ask about this listing or request its COA- FormOral-format capsules, 0.5 mg per capsule, in a sealed bottle
- Research areasMonoamine transporter pharmacology, feeding behavior, reward and motivation circuits
For laboratory research use only. Sold exclusively for in-vitro laboratory research by qualified professionals. Not for human or veterinary use, and not a medicine, food, cosmetic or dietary supplement. Terms and Conditions
Overview
Key facts
Although catalogues often place it among peptides, tesofensine is in fact a synthetic small molecule.
- CAS number
- 402856-42-2
- Purity
- Analytically tested; certificate of analysis available
- Form
- Oral-format capsules, 0.5 mg per capsule, in a sealed bottle
- Storage
- Room temperature, sealed, dry and protected from light
- Available sizes
- 0.5 mg · 30 capsules · 0.5 mg · 60 capsules
For research use only. Not for human consumption.
Although catalogues often place it among peptides, tesofensine is in fact a synthetic small molecule. It blocks the presynaptic reuptake transporters for three monoamines — noradrenaline, dopamine and serotonin. Originally it was pursued for neurodegenerative conditions, where clinical studies missed their goals; appetite and body-weight changes noticed in those trials are what later turned it into a research subject.
Its value as a lab tool lies in hitting all three transporters at once rather than just one. It is used in binding and uptake-inhibition assays that rank affinity across NET, DAT and SERT, in microdialysis experiments tracking extracellular monoamine levels in defined brain regions, and in rodent feeding studies where selective antagonists reveal which neurotransmitter system accounts for reduced intake.
Specifications
Identity
- CAS number
- 402856-42-2
Supply & purity
- Form
- Oral-format capsules, 0.5 mg per capsule, in a sealed bottle
- Purity
- Analytically tested; certificate of analysis available
- Available sizes
- 30 capsules, 60 capsules
Additional detail
- Compound class
- Small-molecule triple monoamine reuptake inhibitor (non-peptide)
- Molecular targets
- Norepinephrine, dopamine and serotonin transporters (NET, DAT, SERT)
- Research areas
- Monoamine transporter pharmacology, feeding behavior, reward and motivation circuits
- Storage
- Room temperature, sealed, dry and protected from light
- Handling note
- Centrally active compound; handle with standard controlled-laboratory precautions
Questions about Tesofensine
Does tesofensine count as a peptide?
No — it is a small-molecule inhibitor of three monoamine reuptake transporters. Shared interest in food-intake research is why it often appears beside metabolic peptides, but chemically and mechanistically it has nothing in common with them.
On which transporters does it act?
NET, DAT and SERT — the transporters for noradrenaline, dopamine and serotonin. How its affinity is spread over those three sets it apart from selective reuptake inhibitors and underlies the behaviour seen in animal work.
In what form do I receive it?
Capsules of 0.5 mg in sealed bottles containing 30 or 60. Unlike most of our range, which is lyophilised powder in vials, nothing has to be reconstituted.
Which documents can I request?
The certificate of analysis for your lot, giving identity and purity. Filing it with your lab notes keeps a clear link between the analytical results and the material you used.
Related
