- Each component assayed to ≥99% (HPLC); per-lot COA on request
- Certificate of analysis tied to your lot number
- Tracked EU delivery, dispatched the next working day
Sermorelin + Ipamorelin
Unmodified GHRH(1-29) fragment combined with a selective ghrelin-receptor pentapeptide
In stock2 formats availableCAS Sermorelin: 86168-78-7 · Ipamorelin: 170851-70-4
€97Range €97 – €165
This listing is currently unavailable. Contact us and we will tell you when it is back or suggest an equivalent.
Ask about this listing or request its COA- FormCo-lyophilized powder, sealed glass vial
- Mol. weightSermorelin: 3357.93 g/mol · Ipamorelin: 711.85 g/mol
- Research areasPituitary somatotroph function, pulsatile GH release, sleep-architecture models, IGF-1 axis, ageing models
For laboratory research use only. Sold exclusively for in-vitro laboratory research by qualified professionals. Not for human or veterinary use, and not a medicine, food, cosmetic or dietary supplement. Terms and Conditions
Overview
Key facts
Sermorelin — GRF(1-29) amide — consists of the first 29 amino acids of human growth hormone-releasing hormone, the shortest stretch that keeps full activity at the receptor.
- CAS number
- Sermorelin: 86168-78-7 · Ipamorelin: 170851-70-4
- Molecular formula
- Sermorelin: C149H246N44O42S · Ipamorelin: C38H49N9O5
- Molecular weight
- Sermorelin: 3357.93 g/mol · Ipamorelin: 711.85 g/mol
- Purity
- ≥99% by HPLC per component; lot-matched COA available
- Form
- Co-lyophilized powder, sealed glass vial
- Storage
- Lyophilized: −20 °C, protected from light and moisture. Reconstituted: 2–8 °C, use within the study window.
- Available sizes
- 10 mg · (5/5) · 20 mg · (10/10)
For research use only. Not for human consumption.
Sermorelin — GRF(1-29) amide — consists of the first 29 amino acids of human growth hormone-releasing hormone, the shortest stretch that keeps full activity at the receptor. Unlike the engineered analogues elsewhere in this category, it has no substitutions and no acyl chain: the sequence is the natural one. That makes it the nearest available stand-in for the body's own GHRH, and it explains why pituitary-function research still treats it as the reference compound whenever an unmodified ligand is preferable to a stabilised one.
Ipamorelin contributes the second pathway. This pentapeptide agonist of the growth hormone secretagogue receptor was developed at Novo Nordisk and found to be remarkably selective: in its original pharmacology it released growth hormone while barely touching ACTH, cortisol or prolactin, in contrast to the older GHRP-6 and GHRP-2. Adding it to sermorelin recruits a second receptor and lowers somatostatin tone, which would otherwise cap how strongly a somatotroph can respond to GHRH.
The pairing is used when researchers want a physiologically realistic stimulus rather than the most stabilised one possible. Peptide Medix EU supplies the two co-lyophilised 1:1 in one sealed vial, HPLC-tested by an independent laboratory with a certificate of analysis for each lot.
What sets this listing apart
Sermorelin + Ipamorelin combines Sermorelin and Ipamorelin in one listing (10/20 mg). Components that are also sold on their own are linked below, each with its own specification and COA.
Same compound, other listings
- Sermorelin
- Ipamorelin
- CJC-1295 DAC + Ipamorelin
- CJC-1295 (No DAC) + Ipamorelin
- Growth Hormone Stack (CJC-1295 · Ipamorelin · Sermorelin vials)
- GH Peptide Starter Kit (CJC-1295 + Ipamorelin 10 mg · Bac Water · Syringes · Pads)
- Ipamorelin + GHRP-2
- Joint & Tendon Stack (BPC-157 · TB-500 · GHK-Cu · Ipamorelin vials)
Specifications
Identity
- CAS number
- Sermorelin: 86168-78-7 · Ipamorelin: 170851-70-4
- Molecular formula
- Sermorelin: C149H246N44O42S · Ipamorelin: C38H49N9O5
- Molecular weight
- Sermorelin: 3357.93 g/mol · Ipamorelin: 711.85 g/mol
- Peptide class
- Native GHRH fragment with a growth hormone secretagogue receptor agonist
Supply & purity
- Form
- Co-lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC per component; lot-matched COA available
- Available sizes
- 10 mg (5 mg/5 mg), 20 mg (10 mg/10 mg)
- Solubility
- Bacteriostatic water
Additional detail
- Blend ratio
- 1:1 Sermorelin to Ipamorelin
- Sermorelin sequence
- Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2 (GRF 1-29 amide)
- Ipamorelin sequence
- Aib-His-D-2-Nal-D-Phe-Lys-NH2
- Research areas
- Pituitary somatotroph function, pulsatile GH release, sleep-architecture models, IGF-1 axis, ageing models
- Storage
- Lyophilized: −20 °C, protected from light and moisture. Reconstituted: 2–8 °C, use within the study window.
Questions about Sermorelin + Ipamorelin
What separates sermorelin from CJC-1295 (No DAC)?
Both are 29-residue GHRH fragments, yet sermorelin keeps the natural sequence whereas CJC-1295 (No DAC) has four DPP-4-resistant substitutions. Sermorelin therefore acts more briefly and more closely resembles endogenous GHRH — why it is still the reference ligand in pituitary research.
What does pairing a GHRH fragment with ipamorelin achieve?
The two hit different receptors on one pituitary cell: sermorelin the GHRH receptor, ipamorelin the ghrelin receptor, which also dampens somatostatin tone that would otherwise limit the response. In animal and cell models, the combination produces a bigger measured growth hormone pulse than either peptide alone.
Is each peptide independently verified?
Yes. Before co-lyophilisation, each component is analysed separately — HPLC for purity, mass spectrometry for identity. The certificate carries the lot number on your vial and can be requested before ordering or after delivery.
What does “20 mg (10/10)” describe?
Total peptide mass, shared equally: 10 mg sermorelin and 10 mg ipamorelin. The smaller vial holds 5 mg of each. They are dried together into one cake, so reconstitution gives a fixed 1:1 solution.
How long does reconstituted sermorelin remain stable?
Not as long as the modified GHRH analogues — the natural sequence is cleaved easily. Keep reconstituted vials at 2–8 °C, protect them from light and repeated warming, and plan study periods accordingly instead of assuming stability over several weeks.
May the blend be used in humans?
No. It is supplied exclusively for in-vitro work and laboratory animal research, without any dosing guidance.
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