- HPLC purity ≥99%, documented per lot
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FOXO4-DRI
D-retro-inverso FOXO4-derived peptide used as a senolytic research tool
In stock1 format availableCAS 2114879-72-6
€182
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Ask about this listing or request its COA- FormLyophilized powder, sealed glass vial
- Mol. weight≈6053 g/mol (see lot COA for exact value)
- Research areasCellular senescence, FOXO4–p53 interaction, senolytics, SASP markers
For laboratory research use only. Sold exclusively for in-vitro laboratory research by qualified professionals. Not for human or veterinary use, and not a medicine, food, cosmetic or dietary supplement. Terms and Conditions
Overview
Key facts
FOXO4-DRI is a synthetic peptide derived from part of the FOXO4 transcription factor and redesigned in D-retro-inverso form: its sequence runs backwards and every amino acid is the D-enantiomer, which roughly preserves the side-chain arrangement of the original L-peptide while…
- CAS number
- 2114879-72-6
- Molecular weight
- ≈6053 g/mol (see lot COA for exact value)
- Purity
- ≥99% by HPLC; lot-matched COA
- Form
- Lyophilized powder, sealed glass vial
- Storage
- −20 °C, protected from light and moisture
- Available size
- 10 mg
For research use only. Not for human consumption.
FOXO4-DRI is a synthetic peptide derived from part of the FOXO4 transcription factor and redesigned in D-retro-inverso form: its sequence runs backwards and every amino acid is the D-enantiomer, which roughly preserves the side-chain arrangement of the original L-peptide while making it far less vulnerable to proteases. A cell-penetrating stretch is built in so the peptide can reach intracellular targets in cultured cells.
It comes as lyophilised powder in a sealed vial, with analytical documentation for the lot. Being a long and strongly charged peptide, it calls for careful planning of reconstitution and storage.
Specifications
Identity
- CAS number
- 2114879-72-6
- Molecular weight
- ≈6053 g/mol (see lot COA for exact value)
- Peptide class
- Cell-penetrating senolytic peptide
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA
- Solubility
- Water or bacteriostatic water; sterile-filter before cell work
Handling & storage
- Storage (lyophilized)
- −20 °C, protected from light and moisture
- Storage (reconstituted)
- 2–8 °C for short-term use; aliquot and freeze for longer studies
Additional detail
- Available size
- 10 mg
- Chirality
- All-D amino acids, retro-inverso orientation
- Parent protein
- FOXO4 forkhead box O transcription factor
- Research areas
- Cellular senescence, FOXO4–p53 interaction, senolytics, SASP markers
Questions about FOXO4-DRI
What is FOXO4-DRI?
A synthetic D-retro-inverso peptide based on the FOXO4 transcription factor, used in the lab as a senolytic tool that disrupts the FOXO4–p53 interaction reported in senescent cells.
What does “D-retro-inverso” mean?
The sequence is reversed and made entirely of D-amino acids instead of the natural L-forms. This keeps the side chains in approximately the same spatial arrangement while giving a protease-resistant backbone, so the peptide lasts longer in experiments.
Is the lot tested by an independent lab?
Yes. HPLC is used to determine purity and mass spectrometry to confirm identity for every lot, and the Certificate of Analysis can be viewed before you buy. Use the net peptide content stated on the COA when you calculate working concentrations.
Which size can I buy?
A single 10 mg lyophilised vial. At about 6053 g/mol, this peptide is so heavy that 10 mg equals far fewer moles than 10 mg of a short peptide like epitalon.
How do I reconstitute it?
Use sterile or bacteriostatic water, adding it gently down the inside of the vial and swirling rather than shaking. As the peptide is long and charged, give it extra time to dissolve and use low-binding labware to limit losses by adsorption.
