- HPLC purity ≥99%, identity confirmed by MS, documented per lot
- Certificate of analysis tied to your lot number
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Melanotan I (Afamelanotide)
Afamelanotide — a 13-residue α-MSH analogue for melanocortin receptor studies
In stock2 formats availableCAS 75921-69-6
€55Range €55 – €97
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Ask about this listing or request its COA- FormWhite to off-white lyophilized powder in a sealed glass vial
- Mol. weight1646.87 g/mol
- Research areasMelanogenesis, eumelanin synthesis, MC1R signalling, UV-response models
For laboratory research use only. Sold exclusively for in-vitro laboratory research by qualified professionals. Not for human or veterinary use, and not a medicine, food, cosmetic or dietary supplement. Terms and Conditions
Overview
Key facts
Melanotan I, known too as afamelanotide, is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH) comprising 13 amino acids.
- CAS number
- 75921-69-6
- Molecular formula
- C78H111N21O19
- Molecular weight
- 1646.87 g/mol
- Amino acid sequence
- Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
- Purity
- ≥99% by HPLC, confirmed by mass spectrometry; lot-matched COA
- Form
- White to off-white lyophilized powder in a sealed glass vial
- Storage
- −20 °C, sealed, protected from light and moisture
- Available sizes
- 10 mg · 20 mg
For research use only. Not for human consumption.
Melanotan I, known too as afamelanotide, is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH) comprising 13 amino acids. Compared with the natural hormone it has two intentional changes — norleucine in position 4 and D-phenylalanine in position 7 — which emerged from structure–activity research on melanocortin ligands and which slow enzymatic degradation without weakening receptor binding. It is a linear tridecapeptide with an amidated C-terminus, and in the lab it acts as a long-lasting melanocortin receptor agonist.
Where the cyclic lactam Melanotan II is constrained, Melanotan I retains the open α-MSH chain and is described as having a narrower melanocortin profile, acting most strongly at MC1R, the subtype found on melanocytes. This relative selectivity is why it appears chiefly in pigmentation, photobiology and receptor-signalling research, not in appetite or sexual-behaviour models, which need broader melanocortin coverage.
What sets this listing apart
Melanotan I (Afamelanotide) – vial, 10/20 mg. White to off-white lyophilized powder in a sealed glass vial. Other Melanotan I listings differ in format, fill or combination partners; the specification and COA always refer to the listing you order.
Same compound, other listings
Specifications
Identity
- CAS number
- 75921-69-6
- Molecular formula
- C78H111N21O19
- Molecular weight
- 1646.87 g/mol
- Amino acid sequence
- Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
- Peptide class
- Linear α-MSH (melanocortin) analog, tridecapeptide
Supply & purity
- Form
- White to off-white lyophilized powder in a sealed glass vial
- Purity
- ≥99% by HPLC, confirmed by mass spectrometry; lot-matched COA
- Available sizes
- 10 mg, 20 mg
- Solubility
- Bacteriostatic water or sterile water; aqueous stocks kept cold and dark
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed, protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, short study window; avoid repeated freeze–thaw
Additional detail
- Primary target
- Melanocortin receptors, with reported preference for MC1R
- Research areas
- Melanogenesis, eumelanin synthesis, MC1R signalling, UV-response models
Questions about Melanotan I (Afamelanotide)
How does Melanotan I compare with natural α-MSH?
It is a synthetic 13-residue version of alpha-melanocyte-stimulating hormone carrying norleucine at position 4 and D-phenylalanine at position 7. Those substitutions reportedly delay enzymatic breakdown and prolong receptor engagement, so in lab assays the analogue outlasts the native hormone as a melanocortin agonist.
Melanotan I versus Melanotan II — what's the difference?
MT-1 is the full-length, linear peptide, with activity concentrated at MC1R. MT-2 is a shorter cyclic lactam that reaches a wider range of melanocortin receptors, MC3R and MC4R included. Comparing them helps separate pigment-pathway signalling from broader melanocortin effects.
Has the lot been checked by an outside lab, and can I read the COA?
Yes. An independent laboratory confirms identity and purity of each production lot using HPLC plus mass spectrometry, and you may request the lot certificate before purchase; it gives lot number, assay value and test date for your files.
Which vial sizes exist, and what's inside?
10 mg and 20 mg lyophilised vials containing nothing but the freeze-dried peptide — no diluent, preservative or excipient — so your lab decides the reconstitution vehicle and final concentration.
How should powder and solutions be kept?
Store the sealed lyophilisate at −20 °C away from light and humidity, where it lasts a long time. After dissolving, refrigerate at 2–8 °C in the dark and use within a short, defined period rather than keeping it long term.
Which solvent is typical in the lab?
Bacteriostatic or sterile water — the peptide dissolves easily. Let the diluent run gently down the glass and swirl rather than shake. Record the solvent together with the concentration, since it influences stability in solution.
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