- HPLC purity ≥99%, with a COA for each lot on request
- Certificate of analysis tied to your lot number
- Tracked EU delivery, dispatched the next working day
MGF (Mechano Growth Factor)
Mechano Growth Factor — 24-residue peptide from the IGF-1 Ec splice variant
In stock2 formats availableCAS 62031-54-3
€51Range €51 – €97
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Ask about this listing or request its COA- FormLyophilized powder, sealed glass vial
- Mol. weight2867.10 g/mol
- Research areasSatellite-cell activation, myoblast proliferation, mechanical-load response, tissue repair models
For laboratory research use only. Sold exclusively for in-vitro laboratory research by qualified professionals. Not for human or veterinary use, and not a medicine, food, cosmetic or dietary supplement. Terms and Conditions
Overview
Key facts
MGF (Mechano Growth Factor) is the peptide corresponding to the E-domain at the C-terminal end of IGF-1 Ec — a splice variant of insulin-like growth factor 1 that skeletal muscle makes for a short time after being loaded mechanically or injured.
- CAS number
- 62031-54-3
- Molecular weight
- 2867.10 g/mol
- Amino acid sequence
- Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Se…
- Purity
- ≥99% by HPLC; lot-matched COA available
- Form
- Lyophilized powder, sealed glass vial
- Storage
- −20 °C, protected from light and moisture
- Available sizes
- 2 mg · 5 mg
For research use only. Not for human consumption.
MGF (Mechano Growth Factor) is the peptide corresponding to the E-domain at the C-terminal end of IGF-1 Ec — a splice variant of insulin-like growth factor 1 that skeletal muscle makes for a short time after being loaded mechanically or injured. What we supply is that 24-residue E-domain on its own, without the mature IGF-1 part of the parent protein — which is why its effects in cell culture and in animals are studied separately from classic IGF-1 signalling.
Interest in MGF arose from exercise-physiology findings that the Ec transcript surges in loaded muscle and then subsides within days, mirroring the period in which satellite cells are recruited. As the isolated E-domain does not engage the IGF-1 receptor the way mature IGF-1 does, several research groups have suggested a separate, receptor-independent mechanism — a question the literature has not yet resolved.
Specifications
Identity
- CAS number
- 62031-54-3
- Molecular weight
- 2867.10 g/mol
- Amino acid sequence
- Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys
- Peptide class
- IGF-1 Ec splice-variant E-domain peptide
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 2 mg, 5 mg
- Solubility
- Bacteriostatic or sterile water; mildly acidic buffers also used in the literature
Handling & storage
- Storage (lyophilized)
- −20 °C, protected from light and moisture
- Storage (reconstituted)
- 2–8 °C; short working window, aliquot and freeze for longer studies
Additional detail
- Residue count
- 24 amino acids
- Also known as
- Mechano Growth Factor, IGF-1 Ec (E-domain), MGF C-terminal peptide
- Research areas
- Satellite-cell activation, myoblast proliferation, mechanical-load response, tissue repair models
Questions about MGF (Mechano Growth Factor)
How is MGF connected to IGF-1?
MGF is the 24-residue E-domain from the C-terminal end of IGF-1 Ec, a splice variant that muscle produces after mechanical strain. Researchers study it apart from mature IGF-1 because it barely binds the IGF-1 receptor and seems to act by another route.
Has an independent lab tested it, and is the COA available?
Yes. An outside laboratory analyses every lot by HPLC and confirms identity by mass spectrometry; the certificate bearing the lot number printed on your vial can be requested before or after you order.
MGF or PEG-MGF — which is which?
PEG-MGF has the identical core peptide with a polyethylene glycol chain attached, which slows both its clearance and its breakdown. The two are often compared in studies that need the peptide to be present for longer than unmodified MGF allows.
Which sizes exist, and what does a vial hold?
2 mg and 5 mg vials of sterile-filtered, lyophilised peptide sealed under vacuum. No diluent is included — bacteriostatic water and reconstitution supplies are sold separately in our lab-supplies section.
What storage does MGF need?
Keep unopened freeze-dried vials in the freezer (−20 °C), shielded from light and humidity, where they stay stable for a long time. After reconstitution, refrigerate at 2–8 °C and use it soon — or portion it out and freeze it — since MGF breaks down in solution faster than most research peptides.
