- HPLC purity ≥99%, with a COA for each lot on request
- Certificate of analysis tied to your lot number
- Tracked EU delivery, dispatched the next working day
Setmelanotide
MC4R-agonist cyclic octapeptide (RM-493) in lyophilised research vials
In stock2 formats availableCAS 920014-72-8
€140Range €140 – €250
This listing is currently unavailable. Contact us and we will tell you when it is back or suggest an equivalent.
Ask about this listing or request its COA- FormLyophilized white to off-white powder, sealed glass vial
- Mol. weight1117.31 g/mol
- Research areasEnergy homeostasis, leptin–POMC signalling, hypothalamic feeding circuits, receptor selectivity profiling
For laboratory research use only. Sold exclusively for in-vitro laboratory research by qualified professionals. Not for human or veterinary use, and not a medicine, food, cosmetic or dietary supplement. Terms and Conditions
Overview
Key facts
Setmelanotide — called RM-493 during development — is an eight-residue peptide closed into a ring that activates the melanocortin-4 receptor (MC4R).
- CAS number
- 920014-72-8
- Molecular formula
- C49H68N18O9S2
- Molecular weight
- 1117.31 g/mol
- Amino acid sequence
- Ac-Arg-Cys-D-Ala-His-D-Phe-Arg-Trp-Cys-NH2, cyclized Cys2–Cys8
- Purity
- ≥99% by HPLC; lot-matched COA available
- Form
- Lyophilized white to off-white powder, sealed glass vial
- Storage
- −20 °C, desiccated and protected from light
- Available sizes
- 5 mg · 10 mg
For research use only. Not for human consumption.
Setmelanotide — called RM-493 during development — is an eight-residue peptide closed into a ring that activates the melanocortin-4 receptor (MC4R). It belongs to the same family of melanocortin analogues as melanotan-II, but was redesigned to prefer MC4R far more strongly than its close relatives MC1R and MC3R, an aim that runs through almost every published account of its pharmacology.
MC4R is a hub of the leptin–POMC circuit in the hypothalamus, which turns signals about the body's energy stores into central control over eating and energy use. Genetic defects further up this chain — in POMC, PCSK1 or the leptin receptor — leave MC4R working but under-stimulated, and that is precisely the situation researchers investigate with a selective MC4R agonist.
Specifications
Identity
- CAS number
- 920014-72-8
- Molecular formula
- C49H68N18O9S2
- Molecular weight
- 1117.31 g/mol
- Amino acid sequence
- Ac-Arg-Cys-D-Ala-His-D-Phe-Arg-Trp-Cys-NH2, cyclized Cys2–Cys8
- Chain length
- 8 residues; N-acetylated, C-terminally amidated, disulfide-cyclized
- Peptide class
- Cyclic melanocortin analogue
Supply & purity
- Form
- Lyophilized white to off-white powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 5 mg, 10 mg
Handling & storage
- Storage (lyophilized)
- −20 °C, desiccated and protected from light
- Storage (reconstituted)
- 2–8 °C for short holds; aliquot at −20 °C or below for longer storage
Additional detail
- Also known as
- RM-493; brand name Imcivree for the approved medicine
- Receptor target
- Melanocortin-4 receptor (MC4R), a Gs-coupled class A GPCR
- Research areas
- Energy homeostasis, leptin–POMC signalling, hypothalamic feeding circuits, receptor selectivity profiling
Questions about Setmelanotide
Which receptor does setmelanotide activate?
MC4R, the melanocortin-4 receptor — a Gs-coupled GPCR in hypothalamic energy-balance circuits. It was built to be selective for MC4R over MC1R and MC3R, which is the main pharmacological difference from older melanocortin analogues like melanotan-II.
How is it different from melanotan-II?
Both are cyclic melanocortin analogues, but melanotan-II binds across the melanocortin family, including the pigment-driving MC1R. Setmelanotide was designed to be far more MC4R-selective, so it is the usual tool when a study must isolate MC4R signalling.
Do you provide a certificate of analysis?
Yes. For every lot, reverse-phase HPLC confirms ≥99% purity and mass spectrometry confirms identity; the certificate is available on request. Check that the lot number on your vial matches it before recording any results.
Setmelanotide is a licensed medicine — is this that product?
No. A prescription medicine containing this molecule is on the market, and we mention it only as background on its regulatory status. We sell research-grade, freeze-dried peptide for use in the lab — not a pharmaceutical product, and without any prescribing information.
How should it be stored?
Keep unopened vials frozen (−20 °C), dry and in the dark. After reconstitution, it can stay in the fridge (2–8 °C) briefly; for longer, freeze single-use portions at −20 °C or colder, because repeated freezing and thawing damages peptides and may break the disulfide bond.
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