- Purity and identity checked by HPLC; per-lot COA on request
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Enclomiphene Citrate — Research Liquid
trans-Clomiphene, a SERM researched in hypothalamic–pituitary–gonadal axis models
In stock1 format availableCAS 7599-79-3 (enclomiphene citrate)
€63
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Ask about this listing or request its COA- FormResearch liquid in a sealed bottle with a graduated dispenser
- Mol. weight405.96 g/mol (free base)
- Research areasHypothalamic-pituitary-gonadal feedback, gonadotropin regulation, secondary hypogonadism models
For laboratory research use only. Sold exclusively for in-vitro laboratory research by qualified professionals. Not for human or veterinary use, and not a medicine, food, cosmetic or dietary supplement. Terms and Conditions
Overview
Key facts
Enclomiphene is the trans geometric isomer of clomiphene, a selective estrogen receptor modulator of the triphenylethylene family.
- CAS number
- 7599-79-3 (enclomiphene citrate)
- Molecular formula
- C26H28ClNO (free base); supplied as the citrate salt
- Molecular weight
- 405.96 g/mol (free base)
- Purity
- HPLC tested for purity and identity; lot-matched COA available
- Form
- Research liquid in a sealed bottle with a graduated dispenser
- Storage
- Cool, dry and dark, tightly capped; refrigeration extends solution stability
- Available size
- 30 mL · 25 mg/mL
For research use only. Not for human consumption.
Enclomiphene is the trans geometric isomer of clomiphene, a selective estrogen receptor modulator of the triphenylethylene family. Clomiphene citrate, as traditionally made, contains two isomers whose pharmacology differs sharply: the cis-isomer zuclomiphene acts mostly as an estrogen receptor agonist and lingers with a long elimination half-life, whereas enclomiphene tends towards antagonism and is cleared much more quickly. Separating out the trans-isomer was intended precisely to pull those two profiles apart.
At the mechanistic level, enclomiphene blocks estrogen receptors in the hypothalamus and pituitary, breaking the negative feedback that estradiol normally applies to gonadotropin-releasing hormone signalling. The effect examined in the literature is a rise in luteinising hormone and follicle-stimulating hormone release and, further downstream, higher endogenous testosterone in male models. That sets it apart from the peptide secretagogues and gonadotropins it is frequently compared with, which work through their own receptors instead of by lifting feedback inhibition.
Specifications
Identity
- CAS number
- 7599-79-3 (enclomiphene citrate)
- Molecular formula
- C26H28ClNO (free base); supplied as the citrate salt
- Molecular weight
- 405.96 g/mol (free base)
Supply & purity
- Form
- Research liquid in a sealed bottle with a graduated dispenser
- Purity
- HPLC tested for purity and identity; lot-matched COA available
Additional detail
- Size and concentration
- 30 mL at 25 mg/mL
- Compound class
- Triphenylethylene selective estrogen receptor modulator (SERM) — not a peptide
- Isomer
- Trans-isomer (E) of clomiphene; the cis-isomer is zuclomiphene
- Molecular target
- Estrogen receptors, with antagonist-predominant activity at hypothalamic and pituitary sites
- Downstream axis
- GnRH pulsatility, LH and FSH secretion, gonadal steroidogenesis
- Research areas
- Hypothalamic-pituitary-gonadal feedback, gonadotropin regulation, secondary hypogonadism models
- Regulatory status
- Not approved for any indication; not a dietary supplement ingredient
- Storage
- Cool, dry and dark, tightly capped; refrigeration extends solution stability
Questions about Enclomiphene Citrate — Research Liquid
What is the difference between enclomiphene and clomiphene?
Clomiphene citrate combines two geometric isomers; enclomiphene is just the trans form — the one that leans towards antagonism and is cleared faster. Its partner, cis-zuclomiphene, is estrogenic and persists for a long time, and splitting the two apart is why enclomiphene was developed as a separate substance.
Does enclomiphene count as a peptide?
No. It is a non-peptide small molecule from the triphenylethylene class and a chemical relative of tamoxifen. It targets estrogen receptors, while peptides it is often set against — gonadorelin or hCG, for example — act on their own receptors in the same hormonal axis.
Which documents are supplied?
We HPLC-test every lot for purity and identity, and the certificate for your lot can be requested. File it with your study records so the characterised material stays linked to the data it produced.
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