- HPLC purity ≥99%, with a COA for each lot on request
- Certificate of analysis tied to your lot number
- Tracked EU delivery, dispatched the next working day
Pentapeptide-18 (Leuphasyl)
[D-Ala2]leucine-enkephalin analogue for neurotransmitter-release research
In stock1 format availableCAS 64963-01-5
€178
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Ask about this listing or request its COA- FormLyophilized powder, sealed glass vial
- Mol. weight569.65 g/mol
- Research areasNeurotransmitter-release models, contraction-associated assays and comparative cosmetic-peptide formulation
For laboratory research use only. Sold exclusively for in-vitro laboratory research by qualified professionals. Not for human or veterinary use, and not a medicine, food, cosmetic or dietary supplement. Terms and Conditions
Overview
Key facts
Pentapeptide-18 — sold as Leuphasyl and also known as [D-Ala2]leucine-enkephalin — is a synthetic peptide of five residues: Tyr-D-Ala-Gly-Phe-Leu.
- CAS number
- 64963-01-5
- Molecular formula
- C29H39N5O7
- Molecular weight
- 569.65 g/mol
- Amino acid sequence
- Tyr-D-Ala-Gly-Phe-Leu-OH
- Purity
- ≥99% by HPLC; lot-matched COA available
- Form
- Lyophilized powder, sealed glass vial
- Storage
- −20 °C lyophilized; protect from light and moisture
- Available size
- 200 mg
For research use only. Not for human consumption.
Pentapeptide-18 — sold as Leuphasyl and also known as [D-Ala2]leucine-enkephalin — is a synthetic peptide of five residues: Tyr-D-Ala-Gly-Phe-Leu. Native leucine-enkephalin reads Tyr-Gly-Gly-Phe-Leu, so the D-alanine replaces the first of its two glycines; this fixes the stereochemistry and is a classic trick from enkephalin structure–activity research to slow cleavage by aminopeptidases. The compound is registered under CAS 64963-01-5, formula C29H39N5O7, molecular weight 569.65 g/mol.
In cosmetic-peptide research, Pentapeptide-18 has been examined in model systems for neurotransmitter release and contraction, often next to Argireline, SNAP-8, Syn-AKE or Vialox. These act at different proposed steps, so a meaningful study compares them in the same cells, tissue and vehicle rather than lumping them together as interchangeable “expression peptides”. Unlike the palmitoylated actives it is often benchmarked against, Pentapeptide-18 has no lipid attached and behaves as a normal water-soluble small peptide — which affects both how it must be formulated and what a permeation experiment can realistically show.
Specifications
Identity
- CAS number
- 64963-01-5
- Molecular formula
- C29H39N5O7
- Molecular weight
- 569.65 g/mol
- Amino acid sequence
- Tyr-D-Ala-Gly-Phe-Leu-OH
- Chain length
- 5 residues
- Peptide class
- Synthetic enkephalin-related pentapeptide
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
Additional detail
- Available size
- 200 mg
- Also known as
- Leuphasyl, Pentapeptide-18, [D-Ala2]leucine-enkephalin
- Research areas
- Neurotransmitter-release models, contraction-associated assays and comparative cosmetic-peptide formulation
- Storage
- −20 °C lyophilized; protect from light and moisture
Questions about Pentapeptide-18 (Leuphasyl)
What sequence defines Pentapeptide-18?
Tyr-D-Ala-Gly-Phe-Leu-OH. The D-configuration of the alanine in position 2 is part of its identity and must be preserved in analytical records and in any comparison materials.
Is it identical to leucine-enkephalin?
Closely related, but not the same. Pentapeptide-18 is [D-Ala2]leucine-enkephalin; swapping in D-alanine alters its conformation and enzymatic stability compared with the natural all-L peptide.
How is it different from Argireline or Syn-AKE?
All three have distinct sequences and proposed targets: Pentapeptide-18 is enkephalin-related, Argireline is a hexapeptide derived from SNAP-25, and Syn-AKE is a modified diaminobutyroyl benzylamide. They should be treated as separate products.
Which purity documents can I obtain?
It is released at ≥99% by reversed-phase HPLC, and the certificate of analysis for your lot is available. Mass confirmation should match the free-acid form containing D-Ala.
What storage conditions apply?
Store the lyophilised peptide at −20 °C, sealed and away from light and humidity. Refrigerate short-term working solutions, and use aliquots for longer studies to minimise repeated freezing and thawing.
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